CMAUP Plant Collective Molecular Activities

Plant Name: Camptotheca acuminata

Taxonomic Information:

Plant ID: NPO12582
Plant Latin Name: Camptotheca acuminata
Taxonomy Genus: Camptotheca
Taxonomy Family: Nyssaceae

Plant External Links:

NCBI TaxonomyDB: 16922
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Small molecule receptor (family A GPCR)	HTR2B;
Isomerase	TOP1;
Protein Kinase	CHEK1; MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
Enzyme_unclassified	MTOR; ALOX12; HSD17B10; NOX4; POLB;
Lyase	CA2;
Nuclear hormone receptor subfamily 1 group A	THRB;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Transcription Factor	HIF1A; TP53;
Unclassified	LMNA; PMP22; GMNN; HBB; THPO;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Enzyme_unclassified	MTOR	Serine/threonine-protein kinase mTOR	P42345	CHEMBL2842
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Isomerase	TOP1	DNA topoisomerase I	P11387	CHEMBL1781
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group A	THRB	Thyroid hormone receptor beta-1	P10828	CHEMBL1947
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	CHEK1	Serine/threonine-protein kinase Chk1	O14757	CHEMBL4630
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Small molecule receptor (family A GPCR)	HTR2B	Serotonin 2b (5-HT2b) receptor	P41595	CHEMBL1833
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	PMP22	Peripheral myelin protein 22	Q01453	CHEMBL1293298
Unclassified	GMNN	Geminin	O75496	CHEMBL1293278
Unclassified	HBB	Hemoglobin beta chain	P68871	CHEMBL4331
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	4.901E-07	2.223E-04	AURKB, FLT3, IGF1R, KDR, MTOR, PIM1
MF	GO:0005488; binding	GO:0005524; ATP binding	9.014E-07	3.505E-04	AURKB, AXL, CDK1, CHEK1, FLT3, IGF1R, KDR, MET, MTOR, PIM1, TOP1, TP53
MF	GO:0003824; catalytic activity	GO:0035173; histone kinase activity	2.265E-06	7.149E-04	AURKB, CDK1, CHEK1
BP	GO:0008152; metabolic process	GO:0010557; positive regulation of macromolecule biosynthetic process	3.208E-06	9.193E-04	AURKB, CDK1, CHEK1, HIF1A, IGF1R, KDR, MET, MTOR, NOX4, NR1H4, THRB, TP53
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	3.434E-06	9.466E-04	AXL, MET, MTOR, NOX4, THPO
BP	GO:0008283; cell proliferation	GO:0001938; positive regulation of endothelial cell proliferation	9.188E-06	2.002E-03	HIF1A, HTR2B, KDR, MTOR
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	9.195E-06	2.002E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0016572; histone phosphorylation	1.079E-05	2.175E-03	AURKB, CDK1, CHEK1
BP	GO:0008152; metabolic process	GO:2000379; positive regulation of reactive oxygen species metabolic process	1.101E-05	2.199E-03	HBB, MTOR, NOX4, TP53
CC	GO:0043226; organelle	GO:0005654; nucleoplasm	1.161E-05	2.277E-03	AURKB, CDK1, CHEK1, GMNN, HIF1A, LMNA, MTOR, NR1H4, PIM1, POLB, SMN1, SMN2, THRB, TOP1, TP53
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	1.951E-05	3.399E-03	HIF1A, LMNA, MTOR, TP53
MF	GO:0005488; binding	GO:0008134; transcription factor binding	2.642E-05	4.392E-03	FLT3, GMNN, HIF1A, MTOR, NR1H4, PIM1, TP53
BP	GO:0065007; biological regulation	GO:0048872; homeostasis of number of cells	2.999E-05	4.911E-03	AXL, FLT3, HIF1A, POLB
BP	GO:0009987; cellular process	GO:0010638; positive regulation of organelle organization	3.482E-05	5.534E-03	AURKB, HIF1A, KDR, MET, MTOR, NOX4, TP53
MF	GO:0005488; binding	GO:0019825; oxygen binding	4.590E-05	6.800E-03	CYP1B1, HBB, NOX4
MF	GO:0060089; molecular transducer activity	GO:0005021; vascular endothelial growth factor-activated receptor activity	4.873E-05	6.981E-03	FLT3, KDR
MF	GO:0060089; molecular transducer activity	GO:0004887; thyroid hormone receptor activity	4.873E-05	6.981E-03	NR1H4, THRB
BP	GO:0009987; cellular process	GO:0055082; cellular chemical homeostasis	5.094E-05	7.180E-03	CA2, HIF1A, HTR2B, NOX4, NPSR1, NR1H4, TP53
BP	GO:0040011; locomotion	GO:0001667; ameboidal-type cell migration	5.431E-05	7.395E-03	CYP1B1, HIF1A, HTR2B, KDR
BP	GO:0032502; developmental process	GO:0009887; animal organ morphogenesis	5.434E-05	7.395E-03	CA2, GMNN, HTR2B, MTOR, POLB, THRB
MF	GO:0003824; catalytic activity	GO:0004674; protein serine/threonine kinase activity	5.925E-05	7.866E-03	AURKB, CDK1, CHEK1, MTOR, PIM1, TOP1
BP	GO:0009987; cellular process	GO:0070228; regulation of lymphocyte apoptotic process	7.515E-05	9.626E-03	AURKB, HIF1A, TP53
CC	GO:0043226; organelle	GO:0005876; spindle microtubule	7.515E-05	9.626E-03	AURKB, CDK1, POLB

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	4.840E-08	4.550E-06	FLT3, TP53, MET, HIF1A, MTOR
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	4.922E-07	2.313E-05	KDR, TP53, HIF1A, MET, MTOR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	2.336E-05	6.586E-04	FLT3, HIF1A, MET, TP53, MTOR, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	2.802E-05	6.586E-04	THRB, TP53, HIF1A, MTOR
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	7.338E-05	1.322E-03	PIM1, CYP1B1, TP53, MET, MTOR
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	8.437E-05	1.322E-03	FLT3, PIM1, MTOR
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	1.249E-04	1.389E-03	TP53, MTOR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	1.404E-04	1.389E-03	KDR, TP53, MET, MTOR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	2.384E-04	1.867E-03	POLB, CHEK1, CDK1, TP53
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	1.625E-04	1.389E-03	TP53, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	1.448E-04	1.389E-03	FLT3, TP53, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	3.170E-04	2.292E-03	TP53, MTOR, IGF1R
09140 Cellular Processes	09143 Cell growth and death	hsa04115	p53 signaling pathway	1.493E-04	1.389E-03	CHEK1, CDK1, TP53
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	3.723E-04	2.500E-03	TP53, MTOR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	4.868E-04	3.050E-03	HIF1A, MTOR, IGF1R
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	6.295E-04	3.699E-03	THPO, FLT3, KDR, MET
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	1.679E-03	8.770E-03	THPO, PIM1, MTOR
09140 Cellular Processes	09143 Cell growth and death	hsa04110	Cell cycle	8.357E-04	4.621E-03	CHEK1, CDK1, TP53

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	HTR2B;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	TOP1; KDR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Lung cancer	C33-C34	TOP1;
C00-D49: Neoplasms	Metastatic breast cancer	C50	TOP1; KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	HTR2B;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Transplant rejection	D89.8, T86	MTOR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	CLL	NA	FLT3;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	TOP1; FLT3;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
C00-D49: Neoplasms	Lymphoma	C81-C86	CHEK1; HIF1A; MTOR;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperthyroidism	E05	THRB;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Organ rejection	D89.8, T86	MTOR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB; TP53;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
C00-D49: Neoplasms	Ovarian cancer	C56	TOP1; KDR;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	TOP1; KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	High cholesterol levels in blood	E78.0	THRB;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; CHEK1; FLT3; MTOR;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; MTOR;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MTOR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Advanced ovarian cancer	NA	TOP1;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced kidney cancer	C64	MTOR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A; HTR2B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychoses	F20-F29	HTR2B;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TOP1; TP53;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3; TP53;
I00-I99: Diseases of the circulatory system	Congestive heart failure	I50	HTR2B;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MTOR;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	THRB;
C00-D49: Neoplasms	Non-hodgkin's lymphoma	C85	MTOR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Beta thalassemia	D56.1	HBB;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Renal cancer	C64	KDR; MTOR;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; TOP1; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	TOP1;
NA: NA	GIST	NA	FLT3;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; TOP1; IGF1R; KDR; CHEK1; FLT3; HIF1A; TP53; MTOR;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Solid tumors	NA	MTOR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; TOP1; AURKB; IGF1R; KDR; CHEK1; FLT3; HIF1A; TP53; MTOR;
I00-I99: Diseases of the circulatory system	Coronary heart disease	I25.1	HTR2B;
S00-T88: Injury, poisoning and certain other consequences of external causes	Wound healing	T14.0-T14.1	THRB;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET; CHEK1;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Bladder cancer	C67	TOP1; MTOR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypothyroidism	E03	THRB;
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	HTR2B;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MTOR;
C00-D49: Neoplasms	Gastric cancer	C16	TOP1; KDR;
I00-I99: Diseases of the circulatory system	Cerebral infarction	I63	HTR2B;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
A00-B99: Certain infectious and parasitic diseases	Dutch elm disease	B81-B83	MTOR;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; CHEK1; AXL; MTOR;
C00-D49: Neoplasms	Sarcoma	C81-C86	MTOR;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TOP1; IGF1R; KDR; FLT3; TP53;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
A00-B99: Certain infectious and parasitic diseases	Acquired immune deficiency syndrome	B20	TOP1;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; MTOR;
NA: NA	Coronary artery restenosis	NA	MTOR;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Esophageal cancer	C15	TOP1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases