CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Cysteine protease	CAPN1;
Transcription Factor	HIF1A; TP53;
SLC superfamily of solute carriers	SLC2A1;
Unclassified	HSP90AA1; HTT; RAB9A; XBP1; NPC1; LMNA;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CAPN1	Calpain 1	P07384	CHEMBL3891
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
SLC superfamily of solute carriers	SLC2A1	Glucose transporter	P11166	CHEMBL2535
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	HSP90AA1	Heat shock protein HSP 90-alpha	P07900	CHEMBL3880
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	XBP1	X-box-binding protein 1	P17861	CHEMBL1741176
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Showing 1 to 10 of 11 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0042149; cellular response to glucose starvation	1.407E-06	6.125E-03	SLC2A1, TP53, XBP1
BP	GO:0008152; metabolic process	GO:0016241; regulation of macroautophagy	2.239E-06	6.966E-03	CAPN1, HIF1A, HTT, NPC1

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09120 Genetic Information Processing	09123 Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	1.233E-04	1.406E-03	XBP1, HSP90AA1, CAPN1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	7.052E-05	1.005E-03	LMNA, CAPN1, TP53
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	4.237E-05	1.005E-03	SLC2A1, TP53, HIF1A
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	7.736E-06	4.410E-04	SLC2A1, TP53, HIF1A
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	6.672E-05	1.005E-03	HSP90AA1, SLC2A1, HIF1A, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	4.283E-04	4.069E-03	XBP1, SLC2A1, TP53
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	6.929E-04	5.643E-03	SLC2A1, HIF1A
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.255E-03	8.945E-03	HSP90AA1, TP53

Showing 1 to 8 of 8 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
C00-D49: Neoplasms	Refractory hematological malignancies	NA	HSP90AA1;
C00-D49: Neoplasms	Breast cancer	C50	HSP90AA1;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A; TP53;
C00-D49: Neoplasms	Multiple myeloma	C90	HSP90AA1;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; TP53; HSP90AA1;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;

Showing 1 to 10 of 20 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Croton californicus

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities