CMAUP Plant Collective Molecular Activities

Plant Name: Castanospermum australe

Taxonomic Information:

Plant ID: NPO12473
Plant Latin Name: Castanospermum australe
Taxonomy Genus: Castanospermum
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 24962
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Australia; India

Traditional Medicine System:

Indian Folk

Medicinal Functions:

Astringent; Miscellany

Geographical Distribution:

Australia; India

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	MGAM; GAA;
Enzyme_unclassified	SI; AGL;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	SI	Sucrase-isomaltase	P14410	CHEMBL2748
Enzyme_unclassified	AGL	Glycogen debranching enzyme	P35573	CHEMBL5272
Hydrolase	MGAM	Maltase-glucoamylase	O43451	CHEMBL2074
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004558; alpha-1,4-glucosidase activity	1.332E-11	9.670E-08	GAA, MGAM, SI
MF	GO:0003824; catalytic activity	GO:0004574; oligo-1,6-glucosidase activity	3.216E-08	6.962E-05	GAA, SI
BP	GO:0008152; metabolic process	GO:0000023; maltose metabolic process	9.649E-08	1.401E-04	GAA, MGAM
MF	GO:0003824; catalytic activity	GO:0032450; maltose alpha-glucosidase activity	9.649E-08	1.401E-04	GAA, MGAM
BP	GO:0032501; multicellular organismal process	GO:0044245; polysaccharide digestion	4.823E-07	5.528E-04	MGAM, SI

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5.511E-11	2.756E-10	MGAM, AGL, GAA, SI
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.217E-08	3.042E-08	MGAM, GAA, SI
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.466E-05	2.444E-05	MGAM, SI, GAA, AGL
09150 Organismal Systems	09154 Digestive system	hsa04973	Carbohydrate digestion and absorption	2.962E-05	3.702E-05	MGAM, SI
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	2.438E-02	2.438E-02	GAA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	MGAM;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Hyperglycemia	R73.9	MGAM;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	MGAM;
A00-B99: Certain infectious and parasitic diseases	Dengue fever	A90	MGAM;
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	MGAM; GAA;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	MGAM;
A00-B99: Certain infectious and parasitic diseases	Acquired immune deficiency syndrome	B20	MGAM;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Muscle disease	M60-M63	MGAM;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases