CMAUP Plant Collective Molecular Activities

Plant Name: Glycyrrhiza yunnanensis

Taxonomic Information:

Plant ID: NPO12465
Plant Latin Name: Glycyrrhiza yunnanensis
Taxonomy Genus: Glycyrrhiza
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 912971
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	MAPK1;
Enzyme_unclassified	HSD17B10; HPGD; ALDH1A1; AKR1B1;
Lysine demethylase	KDM4E;
Transcription Factor	NFKB1;
Unclassified	THPO; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP3A4; CYP2C9; CYP19A1; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.587E-12	5.317E-08	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	8.517E-11	4.636E-07	CYP1A2, CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.075E-10	4.683E-07	CYP19A1, CYP1A2, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.212E-09	3.770E-06	CYP1A2, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	7.907E-09	1.913E-05	CYP19A1, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0044281; small molecule metabolic process	2.178E-08	3.068E-05	AKR1B1, ALDH1A1, CYP19A1, CYP1A2, CYP2C19, CYP2C9, CYP3A4, HPGD, HSD17B10, MAPK1
MF	GO:0005488; binding	GO:0020037; heme binding	2.254E-08	3.068E-05	CYP19A1, CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.626E-08	4.156E-05	CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	6.642E-08	6.833E-05	CYP1A2, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	6.904E-08	6.833E-05	CYP19A1, CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	4.000E-07	3.629E-04	CYP1A2, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	5.322E-07	4.635E-04	CYP19A1, CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0006706; steroid catabolic process	7.803E-07	5.859E-04	CYP19A1, CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.101E-06	7.262E-04	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	1.022E-05	6.016E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0042446; hormone biosynthetic process	1.064E-05	6.098E-03	AKR1B1, CYP19A1, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.532E-09	4.521E-07	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9.923E-08	5.398E-06	CYP2C9, CYP1A2, ALDH1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.265E-07	5.398E-06	CYP2C9, CYP1A2, CYP3A4, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.552E-07	1.165E-05	CYP2C9, CYP1A2, ALDH1A1, AKR1B1, CYP2C19, CYP3A4, CYP19A1, HSD17B10
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.546E-07	8.148E-06	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8.236E-06	1.757E-04	CYP1A2, CYP3A4, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.650E-05	3.017E-04	CYP2C9, CYP1A2, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	5.949E-05	9.519E-04	CYP2C9, MAPK1, CYP2C19
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.155E-04	1.642E-03	LMNA, MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	7.104E-04	8.262E-03	MAPK1, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	8.400E-04	8.262E-03	CYP2C9, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	9.514E-04	8.262E-03	MAPK1, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	7.104E-04	8.262E-03	MAPK1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.131E-03	8.262E-03	MAPK1, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	1.162E-03	8.262E-03	MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	1.162E-03	8.262E-03	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	1.162E-03	8.262E-03	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05131	Shigellosis	9.229E-04	8.262E-03	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	1.226E-03	8.262E-03	MAPK1, NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases