CMAUP Plant Collective Molecular Activities

Plant Name: Myroxylon peruiferum

Plant ID: NPO12418
Plant Latin Name: Myroxylon peruiferum
Taxonomy Genus: Myroxylon
Taxonomy Family: Fabaceae

NCBI TaxonomyDB: 1231556
Plant-of-the-World-Online: n.a.

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ACHE;
Enzyme_unclassified	MIF;
ATP-binding cassette	ABCB1;
Methyl-lysine/arginine binding protein	L3MBTL1;
Unclassified	RAB9A; NPC1;

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCB1	P-glycoprotein 1	P08183	CHEMBL4302
Enzyme_unclassified	MIF	Macrophage migration inhibitory factor	P14174	CHEMBL2085
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008283; cell proliferation	GO:0008283; cell proliferation	7.190E-04	6.995E-01	ABCB1, ACHE, MIF
CC	GO:0044464; cell part	GO:0009986; cell surface	4.125E-04	6.995E-01	ABCB1, ACHE, MIF
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	6.212E-04	6.995E-01	ACHE
MF	GO:0005488; binding	GO:0042802; identical protein binding	6.595E-04	6.995E-01	ACHE, L3MBTL1, MIF, RAB9A
MF	GO:0005215; transporter activity	GO:0005319; lipid transporter activity	8.118E-04	6.995E-01	ABCB1, NPC1
CC	GO:0044464; cell part	GO:0005764; lysosome	2.896E-03	8.552E-01	NPC1, RAB9A
CC	GO:0016020; membrane	GO:0005886; plasma membrane	2.709E-02	1.000E+00	ABCB1, ACHE, L3MBTL1, RAB9A
CC	GO:0043226; organelle	GO:0042470; melanosome	3.097E-02	1.000E+00	RAB9A

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00360	Phenylalanine metabolism	5.090E-03	3.939E-02	MIF
09100 Metabolism	09105 Amino acid metabolism	hsa00350	Tyrosine metabolism	1.046E-02	3.939E-02	MIF
09130 Environmental Information Processing	09131 Membrane transport	hsa02010	ABC transporters	1.313E-02	3.939E-02	ABCB1
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	3.285E-02	4.513E-02	ACHE
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.111E-02	4.513E-02	ABCB1
09100 Metabolism	09103 Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2.817E-02	4.513E-02	ACHE
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	4.012E-02	4.513E-02	RAB9A
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	3.634E-02	4.513E-02	NPC1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	8.587E-02	8.587E-02	ABCB1

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MIF;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	MIF;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Refractory autoimmune diseases	D84.9, M35.9	MIF;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases