Plant Name: Gentiana brachyphylla
Taxonomic Information:
Plant ID: NPO1238
Plant Latin Name: Gentiana brachyphylla
Taxonomy Genus: Gentiana
Taxonomy Family: Gentianaceae
Plant External Links:
NCBI TaxonomyDB:
49939
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
| Unclassified | PAX8 | Paired box protein Pax-8 | Q06710 | CHEMBL2362980 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| CC | GO:0044464; cell part | GO:0005770; late endosome | 2.883E-04 | 5.305E-01 | HTT, RAB9A |
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 4.141E-04 | 5.305E-01 | PAX8 |
| MF | GO:0003824; catalytic activity | GO:0008131; primary amine oxidase activity | 1.242E-03 | 6.258E-01 | MAOA |
| MF | GO:0005488; binding | GO:0034452; dynactin binding | 2.276E-03 | 6.608E-01 | HTT |
| CC | GO:0043226; organelle | GO:0042470; melanosome | 2.075E-02 | 1.000E+00 | RAB9A |
| MF | GO:0005488; binding | GO:0042802; identical protein binding | 3.805E-02 | 1.000E+00 | HTT, RAB9A |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00340 | Histidine metabolism | 4.792E-03 | 2.366E-02 | MAOA |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00360 | Phenylalanine metabolism | 3.396E-03 | 2.366E-02 | MAOA |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00350 | Tyrosine metabolism | 6.982E-03 | 2.366E-02 | MAOA |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 5.788E-03 | 2.366E-02 | PAX8 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 7.977E-03 | 2.366E-02 | MAOA |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00260 | Glycine, serine and threonine metabolism | 7.977E-03 | 2.366E-02 | MAOA |
| 09160 Human Diseases | 09164 Substance dependence | hsa05030 | Cocaine addiction | 9.765E-03 | 2.366E-02 | MAOA |
| 09160 Human Diseases | 09164 Substance dependence | hsa05031 | Amphetamine addiction | 1.333E-02 | 2.440E-02 | MAOA |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00330 | Arginine and proline metabolism | 9.963E-03 | 2.366E-02 | MAOA |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.373E-02 | 2.440E-02 | MAOA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
