CMAUP Plant Collective Molecular Activities

Plant Name: Erycibe schmidtii

Taxonomic Information:

Plant ID: NPO12329
Plant Latin Name: Erycibe schmidtii
Taxonomy Genus: Erycibe
Taxonomy Family: Convolvulaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: 267928-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

Myanmar; India; Cambodia; Vietnam; China; Thailand

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	DRD1;
Lyase	CA12; CA1; CA9; CA13; CA7;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Enzyme_unclassified	AKR1B10; AKR1B1; GFER; HSD17B10; ALOX15; ALDH1A1;
Cysteine protease	CASP1; CASP7;
Toll-like and Il-1 receptors	TLR2;
Transcription Factor	HIF1A;
Unclassified	LMNA; FABP3; FABP5; FABP2; FABP4; APP;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP1A2; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	APP	Beta amyloid A4 protein	P05067	CHEMBL2487

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.305E-11	1.034E-07	CA1, CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.604E-09	5.822E-06	CA1, CA12, CA13, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.585E-09	1.248E-05	CA1, CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	4.374E-08	6.350E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	4.836E-08	6.581E-05	AKR1B1, AKR1B10, APP, CYP1A2, CYP2C19, CYP2D6, PPARD
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	5.440E-08	6.968E-05	CYP1A2, CYP2C19, CYP2D6
MF	GO:0003824; catalytic activity	GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors	4.606E-07	2.896E-04	AKR1B1, AKR1B10, ALDH1A1, XDH
BP	GO:0008152; metabolic process	GO:0017144; drug metabolic process	5.673E-07	3.251E-04	AKR1B1, AKR1B10, ALDH1A1, CYP1A2, CYP2C19, CYP2D6, DRD1, TLR2
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	1.613E-06	8.363E-04	CASP1, HIF1A, LMNA, PPARA, PPARD, TLR2
MF	GO:0005488; binding	GO:0005506; iron ion binding	3.086E-06	1.461E-03	ALOX15, CYP1A2, CYP2C19, CYP2D6, XDH
BP	GO:0032501; multicellular organismal process	GO:0014005; microglia development	6.074E-06	2.467E-03	APP, TLR2
BP	GO:0032501; multicellular organismal process	GO:0032640; tumor necrosis factor production	1.214E-05	4.004E-03	APP, TLR2
CC	GO:0044464; cell part	GO:0005829; cytosol	1.316E-05	4.214E-03	AKR1B1, AKR1B10, ALDH1A1, ALOX15, APP, CA1, CA13, CA7, CASP1, CASP7, FABP2, FABP3, FABP4, FABP5, GFER, HIF1A, LMNA, XDH
MF	GO:0005488; binding	GO:0019825; oxygen binding	3.716E-05	1.079E-02	CYP1A2, CYP2C19, CYP2D6
MF	GO:0003824; catalytic activity	GO:0016614; oxidoreductase activity, acting on CH-OH group of donors	4.222E-05	1.139E-02	AKR1B1, AKR1B10, HSD17B10, XDH
CC	Unclassified;	GO:0097386; glial cell projection	2.719E-04	4.975E-02	AKR1B1, APP

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.256E-11	1.692E-09	CA12, CA1, CA7, CA9, CA13
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	4.791E-10	1.797E-08	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.720E-05	2.828E-04	APP, CYP2D6, ALOX15, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	8.763E-06	2.191E-04	CYP1A2, ALOX15, CYP2C19
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	6.140E-05	7.675E-04	CASP7, CASP1, TLR2
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.158E-04	2.024E-03	AKR1B10, CYP1A2, ALOX15, ALDH1A1, AKR1B1, CYP2C19, HSD17B10, XDH
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.210E-04	1.297E-03	CYP2D6, CYP1A2, CYP2C19
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1.156E-03	7.883E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	8.025E-04	6.687E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	9.134E-04	6.851E-03	AKR1B10, AKR1B1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.885E-05	2.828E-04	CYP1A2, XDH

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
S00-T88: Injury, poisoning and certain other consequences of external causes	Brain injury	S09.90	APP;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	APP;
E00-E89: Endocrine, nutritional and metabolic diseases	Amyloidosis	E85	APP;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
C00-D49: Neoplasms	Glioma	C71	APP;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1;
NA: NA	Geographic retinal atrophy	NA	APP;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
H00-H59: Diseases of the eye and adnexa	Age related macular degeneration	H35.3	APP;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	APP;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	APP;
G00-G99: Diseases of the nervous system G00-G99	Diagnostic imaging	G30, I73.9	APP;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	APP;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	DRD1;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1;
H00-H59: Diseases of the eye and adnexa	Macular degeneration	H35.3	APP;
I00-I99: Diseases of the circulatory system	Cerebral amyloid angiopathy	I68.0	APP;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	APP; CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases