Plant ID: NPO12322
Plant Latin Name: Amomum krervanh
Taxonomy Genus: Amomum
Taxonomy Family: Zingiberaceae
NCBI TaxonomyDB:
649195
Plant-of-the-World-Online:
n.a.
Thailand; Vietnam
TSHR; | |
TRPA1; | |
MAPK1; | |
PPARD; PPARA; | |
THRB; | |
TLR2; | |
TP53; | |
MAPT; FABP3; FABP5; FABP2; FABP4; LMNA; |
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
Nuclear hormone receptor subfamily 1 group A | THRB | Thyroid hormone receptor beta-1 | P10828 | CHEMBL1947 |
Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
Transient receptor potential channel | TRPA1 | Transient receptor potential cation channel subfamily A member 1 | O75762 | CHEMBL6007 |
Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 4.622E-09 | 2.013E-05 | CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 6.595E-09 | 2.187E-05 | FABP2, FABP3, FABP4, FABP5 |
BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 8.120E-08 | 1.040E-04 | CYP1A1, CYP1A2, CYP1B1 |
MF | GO:0005488; binding | GO:0019825; oxygen binding | 7.678E-08 | 1.040E-04 | CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 8.942E-07 | 6.281E-04 | CYP1A1, CYP1A2, CYP1B1 |
BP | GO:0050896; response to stimulus | GO:0009636; response to toxic substance | 1.176E-06 | 7.400E-04 | CYP1A1, CYP1B1, MAPK1, TLR2, TP53, TRPA1 |
BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 1.189E-06 | 7.400E-04 | CYP1A1, CYP1A2, CYP1B1 |
BP | GO:0050896; response to stimulus | GO:0014070; response to organic cyclic compound | 2.301E-06 | 1.119E-03 | CYP1A1, CYP1A2, CYP1B1, MAPK1, TLR2, TP53, TRPA1 |
BP | GO:0050896; response to stimulus | GO:0042493; response to drug | 2.520E-06 | 1.164E-03 | CYP1A1, CYP1B1, FABP3, MAPK1, TLR2, TP53, TRPA1 |
BP | GO:0032502; developmental process | GO:0048856; anatomical structure development | 3.103E-06 | 1.379E-03 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP5, LMNA, MAPK1, PPARA, PPARD, TLR2, TP53, TSHR |
BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 4.916E-06 | 1.946E-03 | CYP1A1, CYP1A2 |
MF | GO:0005488; binding | GO:0020037; heme binding | 5.238E-06 | 2.037E-03 | CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
BP | GO:0007610; behavior | GO:0007610; behavior | 6.472E-06 | 2.473E-03 | MAPK1, MAPT, PPARA, THRB, TLR2, TP53 |
MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 1.219E-05 | 3.961E-03 | PPARA, PPARD, THRB |
MF | GO:0005488; binding | GO:0005506; iron ion binding | 1.267E-05 | 4.058E-03 | CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
MF | GO:0005488; binding | GO:0019902; phosphatase binding | 1.397E-05 | 4.225E-03 | MAPK1, MAPT, PPARA, TP53 |
MF | GO:0005488; binding | GO:0097371; MDM2/MDM4 family protein binding | 1.718E-05 | 4.734E-03 | PPARA, TP53 |
MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 2.138E-05 | 5.609E-03 | PPARA, PPARD, THRB |
BP | GO:0008152; metabolic process | GO:0050665; hydrogen peroxide biosynthetic process | 2.289E-05 | 5.864E-03 | CYP1A1, CYP1A2 |
BP | GO:0008283; cell proliferation | GO:0008285; negative regulation of cell proliferation | 2.926E-05 | 7.323E-03 | CYP1B1, FABP3, LMNA, PPARD, TLR2, TP53 |
BP | GO:0051179; localization | GO:0015908; fatty acid transport | 3.136E-05 | 7.759E-03 | FABP3, PPARA, PPARD |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 2.425E-11 | 3.129E-09 | FABP2, FABP3, FABP4, FABP5, PPARA, PPARD |
09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 1.890E-07 | 1.219E-05 | CYP1A2, CYP1A1, CYP1B1, CYP19A1 |
09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 5.923E-06 | 2.547E-04 | CYP1A2, CYP1A1, CYP1B1 |
09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 1.168E-05 | 3.768E-04 | CYP1A1, CYP1B1, CYP19A1 |
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 3.660E-05 | 9.443E-04 | CYP1A2, CYP1A1, CYP1B1 |
09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 5.185E-05 | 1.115E-03 | CYP1A2, CYP1A1, CYP1B1 |
09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 1.531E-04 | 2.822E-03 | THRB, MAPK1, TP53 |
09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.536E-04 | 3.590E-03 | LMNA, MAPK1, TP53 |
09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 2.181E-04 | 3.516E-03 | MAPK1, PPARA, TP53 |
09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 2.869E-04 | 3.590E-03 | MAPK1, TP53, TLR2 |
09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 7.513E-04 | 6.923E-03 | MAPK1, TP53, TLR2 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 7.092E-04 | 6.923E-03 | MAPK1, PPARA, TSHR |
09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 6.144E-04 | 6.605E-03 | MAPK1, TP53 |
09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 3.062E-04 | 3.590E-03 | MAPK1, TP53 |
09160 Human Diseases | 09161 Cancers | hsa05223 | Non-small cell lung cancer | 1.145E-03 | 8.498E-03 | MAPK1, TP53 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 1.451E-03 | 8.782E-03 | MAPK1, MAPT, TP53 |
09160 Human Diseases | 09161 Cancers | hsa05213 | Endometrial cancer | 9.878E-04 | 8.495E-03 | MAPK1, TP53 |
09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 1.186E-03 | 8.498E-03 | MAPK1, PPARD |
09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 1.145E-03 | 8.498E-03 | FABP4, TSHR |
09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 1.539E-03 | 8.782E-03 | MAPK1, TP53 |
09160 Human Diseases | 09161 Cancers | hsa05210 | Colorectal cancer | 1.401E-03 | 8.782E-03 | MAPK1, TP53 |
09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 1.586E-03 | 8.782E-03 | MAPK1, TP53 |
09160 Human Diseases | 09161 Cancers | hsa05218 | Melanoma | 1.832E-03 | 9.249E-03 | MAPK1, TP53 |
09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 1.634E-03 | 8.782E-03 | MAPK1, TP53 |
09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 1.539E-03 | 8.782E-03 | CYP1A2, CYP1A1 |
09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 1.936E-03 | 9.249E-03 | MAPK1, TP53 |
09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 1.936E-03 | 9.249E-03 | MAPK1, TLR2 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | CYP19A1; |
E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | THRB; |
E00-E89: Endocrine, nutritional and metabolic diseases | Hypothyroidism | E03 | THRB; |
C00-D49: Neoplasms | Solid tumours | C00-D48 | MAPK1; |
N00-N99: Diseases of the genitourinary system | Prostate disease | N42.9 | CYP19A1; |
C00-D49: Neoplasms | Advanced breast cancer | C50 | CYP19A1; |
I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1; |
E00-E89: Endocrine, nutritional and metabolic diseases | Hyperthyroidism | E05 | THRB; |
S00-T88: Injury, poisoning and certain other consequences of external causes | Wound healing | T14.0-T14.1 | THRB; |
C00-D49: Neoplasms | Hormonally-responsive breast cancer | C50 | CYP19A1; |
E00-E89: Endocrine, nutritional and metabolic diseases | High cholesterol levels in blood | E78.0 | THRB; |
C00-D49: Neoplasms | Bladder cancer | C67 | CYP19A1; |
E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | THRB; |
C00-D49: Neoplasms | Breast cancer | C50 | CYP19A1; |
C00-D49: Neoplasms | Cancer | C00-C96 | MAPK1; |