CMAUP Plant Collective Molecular Activities

Plant Name: Aquilaria agallochum

Taxonomic Information:

Plant ID: NPO12265
Plant Latin Name: Aquilaria agallochum
Taxonomy Genus: Aquilaria
Taxonomy Family: Thymelaeaceae

Plant External Links:

NCBI TaxonomyDB: 1472648
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

India

Traditional Medicine System:

Sowa-Rigpa; Indian Folk; Unani; Ayurveda; Siddha

Geographical Distribution:

India

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	FAAH; TDP1; TERT;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Toll-like and Il-1 receptors	TLR2;
Unclassified	FABP3; FABP2; FABP4; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP3A4; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	FAAH	Anandamide amidohydrolase	O00519	CHEMBL2243
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	2.165E-09	5.238E-06	FABP2, FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	6.054E-09	9.416E-06	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	6.642E-08	7.232E-05	CYP1A2, CYP2D6, CYP3A4
BP	GO:0051179; localization	GO:0015908; fatty acid transport	1.289E-07	1.220E-04	FABP3, PPARA, PPARD, PPARG
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	5.322E-07	3.863E-04	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	1.463E-06	8.609E-04	CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0032868; response to insulin	2.431E-06	1.291E-03	FABP3, PPARA, PPARG, TLR2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	2.924E-06	1.481E-03	CYP1A2, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	4.224E-06	2.044E-03	CYP1A2, CYP2D6, CYP3A4
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	4.872E-06	2.306E-03	PPARA, PPARG
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	5.475E-06	2.442E-03	PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	7.305E-06	3.022E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	7.305E-06	3.022E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0019369; arachidonic acid metabolic process	7.356E-06	3.022E-03	CYP1A2, CYP2D6, FAAH
MF	GO:0005488; binding	GO:0050543; icosatetraenoic acid binding	7.305E-06	3.022E-03	FABP3, PPARG
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	9.620E-06	3.809E-03	PPARA, PPARD, PPARG
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	2.410E-05	8.745E-03	FABP3, PPARG, TLR2
BP	GO:0008152; metabolic process	GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter	2.673E-05	9.542E-03	PPARA, PPARD
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	2.844E-05	9.830E-03	PPARA, PPARD, TERT, TLR2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.432E-14	6.874E-13	FABP2, FABP3, FABP4, FABP5, PPARG, PPARA, PPARD
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.392E-05	2.640E-04	CYP2D6, CYP1A2, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.650E-05	2.640E-04	CYP2D6, CYP1A2, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.828E-04	2.193E-03	CYP1A2, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7.355E-04	7.061E-03	CYP1A2, CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9.229E-04	7.383E-03	CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.464E-03	1.004E-02	CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	2.012E-02	1.073E-01	PPARG
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	3.783E-02	1.106E-01	TLR2
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	3.495E-03	2.097E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases