Plant Name: Hemerocallis radix
Taxonomic Information:
Plant ID: NPO12092
Plant Latin Name: Hemerocallis radix
Taxonomy Genus: Hemerocallis
Taxonomy Family: Asphodelaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| CTDSP1; RECQL; TDP1; PTGES; HSD17B1; AKR1B1; HSD17B2; ALOX15; NOX4; | |
| CDC25B; | |
| DAPK1; MAPK1; FLT3; | |
| CA2; CA12; CA7; | |
| AR; | |
| ESRRA; | |
| ALOX5; TYR; XDH; | |
| PREP; | |
| AHR; HIF1A; TP53; | |
| ABCG2; ABCC1; | |
| HTT; LMNA; MAPT; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| ATP-binding cassette | ABCC1 | Multidrug resistance-associated protein 1 | P33527 | CHEMBL3004 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | CTDSP1 | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 | Q9GZU7 | CHEMBL1795098 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | PTGES | Prostaglandin E synthase | O14684 | CHEMBL5658 |
| Enzyme_unclassified | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | P14061 | CHEMBL3181 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Enzyme_unclassified | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | P37059 | CHEMBL2789 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Nuclear hormone receptor subfamily 3 group B | ESRRA | Estrogen-related receptor alpha | P11474 | CHEMBL3429 |
| Nuclear hormone receptor subfamily 3 group C | AR | Androgen Receptor | P10275 | CHEMBL1871 |
| Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
| Oxidoreductase | TYR | Tyrosinase | P14679 | CHEMBL1973 |
| Oxidoreductase | XDH | Xanthine dehydrogenase | P47989 | CHEMBL1929 |
| Protein Kinase | DAPK1 | Death-associated protein kinase 1 | P53355 | CHEMBL2558 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Protein Kinase | FLT3 | Tyrosine-protein kinase receptor FLT3 | P36888 | CHEMBL1974 |
| Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
| Serine protease | PREP | Prolyl endopeptidase | P48147 | CHEMBL3202 |
| Transcription Factor | AHR | Aryl hydrocarbon receptor | P35869 | CHEMBL3201 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 2.730E-12 | 2.973E-08 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4, NOX4 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 5.608E-12 | 3.323E-08 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 1.943E-11 | 5.288E-08 | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4, XDH |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.904E-10 | 3.769E-07 | CYP1A2, CYP2C19, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 4.458E-10 | 8.089E-07 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 5.060E-09 | 5.509E-06 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4, NOX4 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 6.231E-09 | 6.167E-06 | CYP1A2, CYP2C19, CYP2C9, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 2.806E-08 | 1.971E-05 | CYP1A2, CYP2C9, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 1.097E-07 | 6.127E-05 | CYP1A1, CYP1A2, CYP1B1, CYP3A4 |
| BP | GO:0050896; response to stimulus | GO:0033993; response to lipid | 9.150E-07 | 3.985E-04 | AR, CA2, CYP1A1, CYP1A2, ESRRA, FLT3, HSD17B2, PTGES, TP53, TYR |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 1.527E-06 | 6.272E-04 | CYP1A2, CYP2C9, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 3.144E-06 | 1.141E-03 | CA12, CA2, CA7 |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 8.929E-06 | 2.818E-03 | AKR1B1, HIF1A, MAPK1, MAPT |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 1.129E-05 | 3.323E-03 | CA2, CA7 |
| MF | GO:0003824; catalytic activity | GO:0070576; vitamin D 24-hydroxylase activity | 1.129E-05 | 3.323E-03 | CYP1A1, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 1.211E-05 | 3.469E-03 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 2.256E-05 | 5.645E-03 | CYP1A1, CYP1A2 |
| MF | GO:0005488; binding | GO:0005496; steroid binding | 2.408E-05 | 5.959E-03 | AR, CYP3A4, ESRRA, HSD17B1 |
| BP | GO:0008152; metabolic process | GO:2000379; positive regulation of reactive oxygen species metabolic process | 2.882E-05 | 7.050E-03 | MAPT, NOX4, TP53, XDH |
| BP | GO:0008152; metabolic process | GO:0006691; leukotriene metabolic process | 3.040E-05 | 7.273E-03 | ABCC1, ALOX15, ALOX5 |
| MF | GO:0005488; binding | GO:0051879; Hsp90 protein binding | 3.349E-05 | 7.842E-03 | AHR, HIF1A, MAPT |
| BP | GO:0050896; response to stimulus | GO:0034097; response to cytokine | 3.531E-05 | 8.172E-03 | ALOX15, DAPK1, FLT3, HIF1A, MAPK1, PTGES, TP53 |
| BP | GO:0065007; biological regulation | GO:0030641; regulation of cellular pH | 3.565E-05 | 8.172E-03 | CA2, CA7, MAPK1, TP53 |
| MF | GO:0003824; catalytic activity | GO:0101020; estrogen 16-alpha-hydroxylase activity | 3.755E-05 | 8.516E-03 | CYP1A1, CYP3A4 |
| CC | GO:0016020; membrane | GO:0005789; endoplasmic reticulum membrane | 5.719E-05 | 1.092E-02 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4, HSD17B2, NOX4, PTGES |
| CC | GO:0044464; cell part | GO:0005829; cytosol | 8.375E-05 | 1.414E-02 | AHR, AKR1B1, ALOX15, ALOX5, AR, CA2, CA7, CDC25B, FLT3, HIF1A, HSD17B1, HTT, LMNA, MAPK1, MAPT, PREP, SMN1, SMN2, TP53, TYR, XDH |
| CC | GO:0044464; cell part | GO:0005641; nuclear envelope lumen | 1.047E-04 | 1.665E-02 | ALOX5, PTGES |
| CC | GO:0043226; organelle | GO:0043231; intracellular membrane-bounded organelle | 1.800E-04 | 2.405E-02 | ABCG2, AHR, AKR1B1, AR, CTDSP1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4, ESRRA, FLT3, HIF1A, HTT, LMNA, MAPK1, MAPT, NOX4, PREP, RECQL, SMN1, SMN2, TDP1, TP53, TYR, XDH |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 1.171E-09 | 1.439E-07 | HSD17B1, CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP3A4 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 2.164E-09 | 1.439E-07 | CYP2C9, CYP1A2, ALOX15, CYP3A4, CYP2C19 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 3.750E-08 | 1.247E-06 | HSD17B1, ALOX5, HSD17B2, CYP1A1, CYP1B1 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 9.805E-09 | 4.347E-07 | CYP2C9, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 1.127E-07 | 2.997E-06 | CYP2C9, ALOX5, ALOX15, CYP2C19, PTGES |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 2.344E-07 | 4.894E-06 | ALOX15, AKR1B1, CYP2C19, CYP3A4, TYR, CYP2C9, HSD17B1, ALOX5, HSD17B2, CYP1A2, CYP1A1, XDH, PTGES |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 2.576E-07 | 4.894E-06 | CYP2C9, CYP1A2, CYP1A1, CYP1B1, CYP3A4 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 2.180E-06 | 3.625E-05 | CYP2C9, ALOX5, ALOX15, MAPK1, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 7.792E-06 | 9.421E-05 | FLT3, MAPK1, TP53, HIF1A |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 6.901E-06 | 9.179E-05 | CYP2C9, CYP1A2, CYP1A1, CYP3A4 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 8.764E-06 | 9.714E-05 | CYP2C9, CYP1A2, CYP3A4, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 9.499E-05 | 7.896E-04 | AR, FLT3, DAPK1, MAPK1, HIF1A, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 2.345E-04 | 1.835E-03 | ABCC1, CYP1B1, MAPK1, TP53, CDC25B |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 5.956E-05 | 5.658E-04 | CYP1A2, CYP1A1, CYP1B1 |
| 09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 6.417E-05 | 5.690E-04 | DAPK1, MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 6.420E-04 | 4.494E-03 | AR, MAPK1, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 1.355E-03 | 8.751E-03 | MAPK1, MAPT, TP53, CDC25B |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 3.308E-04 | 2.444E-03 | CA2, CYP3A4, ABCG2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 1.453E-03 | 8.783E-03 | MAPK1, TP53, HIF1A |
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 4.225E-06 | 6.243E-05 | CA12, CA2, CA7 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 1.525E-03 | 8.816E-03 | ABCC1, MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 1.382E-03 | 8.751E-03 | MAPK1, TP53 |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 3.503E-05 | 3.583E-04 | CYP1A2, XDH |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| NA: NA | HIV infections | NA | AHR; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Melasma | L81.1 | TYR; |
| C00-D49: Neoplasms | Melanoma | C43 | TYR; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Vitiligo | L80 | TYR; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | AHR; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | TYR; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
