CMAUP Plant Collective Molecular Activities

Plant Name: Crataegus pinnatifida

Taxonomic Information:

Plant ID: NPO12011
Plant Latin Name: Crataegus pinnatifida
Taxonomy Genus: Crataegus
Taxonomy Family: Rosaceae

Plant External Links:

NCBI TaxonomyDB: 510735
Plant-of-the-World-Online: 724002-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Alterative; Antibacterial; Anticholesterolemic; Antidote; Antiscorbutic; Cardiotonic; Deobstruent; Hypotensive; Laxative; Stimulant; Stomachic; Vasodilator

Geographical Distribution:

Iran; South Africa; Uzbekistan; China; Japan; Russia

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CHRM1; FFAR1; FFAR4; CHRM2; CHRM3; CHRM4; CHRM5;
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Protein Phosphatase	CDC25B;
Enzyme_unclassified	ALPL; RECQL; PGD; ALOX12; HSD17B2; HSD17B10; ALOX15; NOX4; POLB;
Hydrolase	ACHE;
Miscellaneous ion channel	BCL2;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
Lyase	CA2; CA12; CA14; CA7; CA4;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	TYR;
Lysine demethylase	KDM4E;
Transcription Factor	AHR; NFKB1;
Transferase	FUT7;
Unclassified	LMNA; FABP3;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	PGD	6-phosphogluconate dehydrogenase	P52209	CHEMBL3404
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Small molecule receptor (family A GPCR)	CHRM1	Muscarinic acetylcholine receptor M1	P11229	CHEMBL216
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Small molecule receptor (family A GPCR)	CHRM2	Muscarinic acetylcholine receptor M2	P08172	CHEMBL211
Small molecule receptor (family A GPCR)	CHRM3	Muscarinic acetylcholine receptor M3	P20309	CHEMBL245
Small molecule receptor (family A GPCR)	CHRM4	Muscarinic acetylcholine receptor M4	P08173	CHEMBL1821
Small molecule receptor (family A GPCR)	CHRM5	Muscarinic acetylcholine receptor M5	P08912	CHEMBL2035
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0007197; adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway	7.645E-14	8.324E-10	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
MF	GO:0060089; molecular transducer activity	GO:0016907; G-protein coupled acetylcholine receptor activity	7.645E-14	8.324E-10	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
BP	GO:0050896; response to stimulus	GO:0007207; phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway	4.579E-13	3.323E-09	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.254E-10	7.011E-07	CA12, CA14, CA2, CA4, CA7
BP	GO:0023052; signaling	GO:0007271; synaptic transmission, cholinergic	5.925E-09	9.004E-06	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	7.723E-08	6.468E-05	CA12, CA14, CA2, CA4, CA7
MF	Unclassified;	GO:0004872; receptor activity	8.746E-08	6.801E-05	AHR, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FFAR1, FFAR4, FLT3, IGF1R, KDR, MET, NPSR1, NR1H4, RORC, TSHR
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	8.577E-07	4.151E-04	ALOX12, AURKB, AXL, BCL2, CDK1, FFAR4, IGF1R, KDR, LMNA, NFKB1, NR1H4, PIM1
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.707E-06	6.633E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.865E-06	7.000E-04	CA12, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0019825; oxygen binding	4.640E-06	1.464E-03	CYP1A1, CYP1A2, CYP1B1, NOX4
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	5.168E-06	1.585E-03	AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FFAR1, FFAR4, FLT3, IGF1R, KDR, MET, NPSR1, TSHR
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	6.047E-06	1.650E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	6.047E-06	1.650E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	9.586E-06	2.456E-03	ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, HSD17B10, HSD17B2, KDM4E, NOX4, PGD, TYR
BP	GO:0032501; multicellular organismal process	GO:0007399; nervous system development	1.429E-05	3.489E-03	ACHE, CHRM1, CHRM2, CHRM3, SMN1, SMN2, TSHR
BP	GO:0050896; response to stimulus	GO:0010243; response to organonitrogen compound	1.443E-05	3.489E-03	CDK1, FABP3, FFAR4, FLT3, IGF1R, NFKB1, NOX4, NR1H4, TSHR, TYR
BP	GO:0065007; biological regulation	GO:0048878; chemical homeostasis	1.578E-05	3.736E-03	ALOX12, BCL2, CA12, CA2, CA7, FABP3, FFAR1, MET, NOX4, NPSR1, NR1H4
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.811E-05	4.066E-03	CA2, CA7
BP	GO:0019740; nitrogen utilization	GO:0006808; regulation of nitrogen utilization	1.811E-05	4.066E-03	BCL2, NR1H4
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	1.811E-05	4.066E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	1.811E-05	4.066E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.856E-05	4.124E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0032502; developmental process	GO:0007568; aging	2.211E-05	4.766E-03	AURKB, BCL2, CDK1, CYP1A1, NOX4, POLB
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	2.391E-05	5.104E-03	ALPL, CYP1A1, CYP1B1, FLT3, NFKB1, NOX4, RORC
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	2.463E-05	5.150E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.463E-05	5.150E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	3.056E-05	5.995E-03	ALPL, BCL2, CA2, CYP1A2, FABP3, FFAR4, FLT3, NFKB1, TSHR
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	3.285E-05	6.330E-03	ACHE, CYP1A1, CYP1B1, FFAR1, FFAR4, HSD17B2, NFKB1, NR1H4
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.617E-05	6.848E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0004435; phosphatidylinositol phospholipase C activity	4.039E-05	7.398E-03	CHRM1, CHRM3, CHRM5
MF	GO:0005488; binding	GO:0005506; iron ion binding	4.704E-05	8.466E-03	ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	5.285E-05	9.433E-03	ALOX12, BCL2, CDC25B, CDK1, CHRM1, FLT3, IGF1R, KDR, PIM1, TSHR
BP	GO:0040011; locomotion	GO:0040012; regulation of locomotion	5.594E-05	9.823E-03	ALOX12, BCL2, CHRM1, CHRM4, CYP1B1, IGF1R, KDR, LMNA, MET, NOX4

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	8.176E-09	5.274E-07	CHRM2, CHRM3, ACHE, CHRM1, CHRM4, CHRM5, BCL2
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.891E-10	5.019E-08	CA12, CA2, CA4, CA7, CA14
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	6.201E-06	2.666E-04	HSD17B2, CYP1A1, CYP1B1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	1.590E-05	4.103E-04	CHRM2, CHRM1, KDR, BCL2, MET, NFKB1, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.126E-05	3.633E-04	CYP1A2, HSD17B2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5.035E-05	1.083E-03	CHRM2, CHRM3, CHRM1, CHRM4, CHRM5, TSHR
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	7.406E-05	1.365E-03	PIM1, BCL2, CYP1B1, MET, NFKB1, CDC25B
09140 Cellular Processes	09142 Cell motility	hsa04810	Regulation of actin cytoskeleton	1.576E-04	2.259E-03	CHRM2, CHRM3, CHRM1, CHRM4, CHRM5
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.204E-04	1.942E-03	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	3.466E-04	4.471E-03	FLT3, PIM1, NFKB1
Unclassified	Unclassified	hsa01100	Metabolic pathways	6.041E-04	7.084E-03	FUT7, HSD17B2, CYP1A2, ALOX15, CYP1A1, ALPL, ALOX12, PGD, TYR, HSD17B10
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	9.065E-04	8.353E-03	CHRM2, CHRM3, CHRM1, CHRM5
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.172E-04	7.709E-03	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	9.065E-04	8.353E-03	FLT3, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.275E-03	9.427E-03	BCL2, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.314E-03	9.427E-03	CHRM2, CHRM1, NFKB1, TSHR
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	1.389E-03	9.427E-03	KDR, BCL2, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.006E-03	8.650E-03	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.382E-03	9.427E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
NA: NA	Excessive sweating	NA	CHRM1;
NA: NA	Extrapyramidal disorders secondary to neuroleptic drug therapy	NA	CHRM1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	CHRM4;
NA: NA	Gastritis	NA	CHRM4;
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	CHRM4;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Stabilize muscle contractions	M00-M99	CHRM2;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3; BCL2;
G00-G99: Diseases of the nervous system G00-G99	Brain diseases	G00-G99	CHRM5;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Postoperative nausea and vomiting	R11	CHRM3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	CHRM4;
K00-K95: Diseases of the digestive system	Colitis	K50-K52	CHRM5;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE; CHRM4;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	CHRM1;
C00-D49: Neoplasms	Melanoma	C43	KDR; TYR;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
NA: NA	Abdominal stomach pain	NA	CHRM1;
H00-H59: Diseases of the eye and adnexa	Acquired nystagmus	H55	CHRM4;
NA: NA	Moderate and severe psychomotor agitation	NA	CHRM4;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnosing bronchial hyperreactivity	W88	CHRM3;
NA: NA	HIV infections	NA	AHR;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	CHRM5;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; CHRM1; CHRM2; CHRM3; CHRM4;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR; BCL2;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; NFKB1; FLT3; ACHE; CDC25B; BCL2;
J00-J99: Diseases of the respiratory system	Bronchodilator	J45	CHRM4;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; CHRM4;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	CHRM1;
G00-G99: Diseases of the nervous system G00-G99	Amyotrophic lateral sclerosis	G12.2	BCL2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
NA: NA	Spasms	NA	CHRM3;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
G00-G99: Diseases of the nervous system G00-G99	Central and peripheral nervous diseases	G96.9	CHRM4; CHRM5;
NA: NA	Suprapubic pain	NA	CHRM4;
K00-K95: Diseases of the digestive system	Stomach ulcer	K25-K27	CHRM1; CHRM5;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; CHRM1; CHRM5;
C00-D49: Neoplasms	CLL	NA	FLT3;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	CHRM5;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	TYR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	CHRM1; CHRM3; CHRM4; CHRM5;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
NA: NA	Addiction	NA	CHRM2;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced melanoma	C43	BCL2;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
NA: NA	Functional bowel syndrome	NA	CHRM1;
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	CHRM4;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Organophosphate poisoning	T60.0	CHRM4;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Visceral spasms	R25.2	CHRM1;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
NA: NA	Vomiting	NA	CHRM4;
J00-J99: Diseases of the respiratory system	Obstructive lung diseases	J40-J44, J47	CHRM3;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE; CA2;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3; BCL2;
NA: NA	Uveitis	NA	CHRM4;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; ACHE; CHRM3;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;
K00-K95: Diseases of the digestive system	Pancreatitis	K85, K86.0K86.1	CHRM4;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE; CHRM1; CHRM2; CHRM4;
NA: NA	Peptic ulcer disease	NA	CHRM4;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	CHRM4;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	CHRM1; CHRM2; CHRM3; CHRM5;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Urinary retention	R33	CHRM4;
NA: NA	Upper abdominal bloating	NA	ACHE;
NA: NA	Urgency	NA	CHRM4;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR; CHRM2;
N00-N99: Diseases of the genitourinary system	Overactive bladder	N32.81	CHRM3;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	CHRM1; CHRM3; CHRM4;
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	CHRM1; CHRM2; CHRM4;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; FFAR1;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
J00-J99: Diseases of the respiratory system	Asthma	J45	CHRM2;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	CHRM2; CHRM4;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3; BCL2;
H00-H59: Diseases of the eye and adnexa	Produce mydriasis and cycloplegia for diagnostic purposes	H57.04	CHRM4;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3; BCL2;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	CHRM4;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
C00-D49: Neoplasms	Lymphoma	C81-C86	BCL2;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE; CHRM5;
H00-H59: Diseases of the eye and adnexa	Mydriasis diagnosis	H57.0	CHRM4;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	CHRM1; CHRM4; CHRM5;
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	CHRM3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nocturia	R35	CHRM4;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	CHRM1;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1; CHRM1; CHRM5;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
NA: NA	Dystonia	NA	CHRM1;
NA: NA	Dysuria	NA	CHRM4;
NA: NA	Schizoaffective disorders	NA	CHRM1;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
I00-I99: Diseases of the circulatory system	Heart failure	I50	CHRM2;
C00-D49: Neoplasms	Colon cancer	C50	FLT3; ALPL;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
NA: NA	Edema	NA	CA2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Sjogren's syndrome	M35.0	CHRM3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CHRM1; CHRM5;
L00-L99: Diseases of the skin and subcutaneous tissue	Seborrhea	L21	CHRM3;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Amnesia	F04	CHRM5;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	CHRM4;
NA: NA	GIST	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; CHRM1; CHRM3; CHRM4;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases