CMAUP Plant Collective Molecular Activities

Plant Name: Ruscus hypoglossum

Taxonomic Information:

Plant ID: NPO11950
Plant Latin Name: Ruscus hypoglossum
Taxonomy Genus: Ruscus
Taxonomy Family: Asparagaceae

Plant External Links:

NCBI TaxonomyDB: 191652
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Turkey

Traditional Medicine System:

Geographical Distribution:

Turkey

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Kinase	IKBKB;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	AKR1B10;
Unclassified	MCL1; TXN2; TXN;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Kinase	IKBKB	Inhibitor of nuclear factor kappa B kinase beta subunit	O14920	CHEMBL1991
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Unclassified	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361
Unclassified	TXN2	Thioredoxin, mitochondrial	Q99757	CHEMBL2189153
Unclassified	TXN	Thioredoxin	P10599	CHEMBL2010624

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	3.377E-07	3.676E-03	GPBAR1, NR1H4
BP	GO:0008152; metabolic process	GO:0006662; glycerol ether metabolic process	6.182E-06	4.487E-02	TXN, TXN2
BP	GO:0009987; cellular process	GO:0060548; negative regulation of cell death	1.836E-04	2.509E-01	IKBKB, MCL1, NR1H4, TXN
BP	GO:0009987; cellular process	GO:0010803; regulation of tumor necrosis factor-mediated signaling pathway	1.907E-04	2.509E-01	IKBKB, NR1H4
BP	GO:0009987; cellular process	GO:0045454; cell redox homeostasis	2.764E-04	2.509E-01	TXN, TXN2
CC	GO:0032991; macromolecular complex	GO:0097136; Bcl-2 family protein complex	2.173E-03	5.735E-01	MCL1
CC	GO:0044464; cell part	GO:0005739; mitochondrion	8.520E-03	1.000E+00	MCL1, TXN, TXN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	9.984E-04	4.593E-02	IKBKB, MCL1
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	5.752E-03	5.813E-02	IKBKB, MCL1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	4.394E-03	5.813E-02	IKBKB, MCL1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1.253E-02	5.813E-02	AKR1B10
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04930	Type II diabetes mellitus	1.668E-02	5.813E-02	IKBKB
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.978E-02	5.813E-02	IKBKB
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.045E-02	5.813E-02	AKR1B10
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	2.528E-02	5.813E-02	IKBKB
09150 Organismal Systems	09151 Immune system	hsa04622	RIG-I-like receptor signaling pathway	2.425E-02	5.813E-02	IKBKB
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.459E-02	5.813E-02	NR1H4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	MCL1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases