CMAUP Plant Collective Molecular Activities

Plant Name: Castanea mollissima

Taxonomic Information:

Plant ID: NPO1191
Plant Latin Name: Castanea mollissima
Taxonomy Genus: Castanea
Taxonomy Family: Fagaceae

Plant External Links:

NCBI TaxonomyDB: 60419
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Antidote; Astringent; Stomachic

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Toll-like and Il-1 receptors	TLR2;
Transcription Factor	TP53;
Unclassified	FABP3; FABP5; LMNA; FABP2; FABP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.517E-09	5.504E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	2.165E-09	6.734E-06	FABP2, FABP3, FABP4, FABP5
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.529E-08	3.441E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.626E-08	3.962E-05	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	4.000E-07	2.722E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	5.322E-07	3.408E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0032502; developmental process	GO:0048856; anatomical structure development	6.041E-07	3.484E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP5, LMNA, PPARA, PPARD, TLR2, TP53, TSHR
MF	GO:0005488; binding	GO:0020037; heme binding	1.749E-06	8.280E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	2.924E-06	1.275E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0005506; iron ion binding	4.254E-06	1.684E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008283; cell proliferation	GO:0008285; negative regulation of cell proliferation	5.363E-06	2.086E-03	CYP1B1, FABP3, LMNA, PPARD, TLR2, TP53
MF	GO:0005488; binding	GO:0097371; MDM2/MDM4 family protein binding	1.022E-05	3.533E-03	PPARA, TP53
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	1.363E-05	4.564E-03	CYP1A1, CYP1A2
BP	GO:0051179; localization	GO:0015908; fatty acid transport	1.413E-05	4.661E-03	FABP3, PPARA, PPARD
BP	GO:0050896; response to stimulus	GO:0042060; wound healing	2.148E-05	6.879E-03	PPARA, PPARD, TP53
BP	GO:0008152; metabolic process	GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter	2.673E-05	8.198E-03	PPARA, PPARD
MF	GO:0005488; binding	GO:0036041; long-chain fatty acid binding	2.673E-05	8.198E-03	FABP3, PPARD

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	3.966E-12	2.856E-10	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6.236E-08	2.245E-06	CYP1A2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.657E-06	6.376E-05	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	5.249E-06	9.448E-05	CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.650E-05	2.376E-04	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.340E-05	2.809E-04	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6.858E-04	7.054E-03	FABP4, TSHR
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9.229E-04	8.306E-03	CYP1A2, CYP1A1
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	3.959E-03	2.338E-02	TP53, TLR2
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	3.495E-03	2.338E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases