Plant Name: Morus australis
Taxonomic Information:
Plant ID: NPO11796
Plant Latin Name: Morus australis
Taxonomy Genus: Morus
Taxonomy Family: Moraceae
Plant External Links:
NCBI TaxonomyDB:
66392
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
India; Indonesia; China; VietnamTraditional Medicine System:
Sowa-Rigpa; TCM; Unani; Ayurveda; SiddhaMedicinal Functions:
Anthelmintic; Aromatic; Astringent; Febrifuge; Laxative; Purgative
Geographical Distribution:
India; Indonesia; China; Vietnam
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| BCHE; ACHE; | |
| BACE1; | |
| SLC22A6; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP19A1; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Hydrolase | BCHE | Butyrylcholinesterase | P06276 | CHEMBL1914 |
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| SLC superfamily of solute carriers | SLC22A6 | Solute carrier family 22 member 6 | Q4U2R8 | CHEMBL1641347 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0003990; acetylcholinesterase activity | 1.126E-07 | 2.451E-03 | ACHE, BCHE |
| MF | GO:0005488; binding | GO:0001540; amyloid-beta binding | 9.885E-07 | 7.175E-03 | ACHE, BACE1, BCHE |
| BP | GO:0008152; metabolic process | GO:0042447; hormone catabolic process | 1.348E-05 | 7.336E-02 | ACHE, CYP19A1 |
| MF | GO:0005488; binding | GO:0042165; neurotransmitter binding | 1.480E-04 | 3.581E-01 | ACHE, BCHE |
| CC | GO:0044464; cell part | GO:0009986; cell surface | 7.068E-04 | 5.260E-01 | ACHE, BACE1, TSHR |
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 7.247E-04 | 5.260E-01 | TSHR |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 1.876E-03 | 8.274E-01 | SLC22A6, TSHR |
| CC | GO:0044464; cell part | GO:0005641; nuclear envelope lumen | 2.896E-03 | 1.000E+00 | BCHE |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 1.737E-02 | 5.464E-02 | CYP19A1 |
| 09160 Human Diseases | 09162 Immune diseases | hsa05320 | Autoimmune thyroid disease | 1.841E-02 | 5.464E-02 | TSHR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 1.944E-02 | 5.464E-02 | TSHR |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 2.013E-02 | 5.464E-02 | CYP19A1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 2.459E-02 | 5.464E-02 | TSHR |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 2.562E-02 | 5.464E-02 | LMNA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04725 | Cholinergic synapse | 3.821E-02 | 5.732E-02 | ACHE |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 2.870E-02 | 5.464E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 3.108E-02 | 5.464E-02 | LMNA |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00564 | Glycerophospholipid metabolism | 3.278E-02 | 5.464E-02 | ACHE |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
