CMAUP Plant Collective Molecular Activities

Plant Name: Magnolia obovata

Taxonomic Information:

Plant ID: NPO11791
Plant Latin Name: Magnolia obovata
Taxonomy Genus: Magnolia
Taxonomy Family: Magnoliaceae

Plant External Links:

NCBI TaxonomyDB: 349509
Plant-of-the-World-Online: 554784-1

Used in Medicines:

Country/Region:

South Korea; China

Traditional Medicine System:

TCM

Geographical Distribution:

Japan; South Korea; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CNR1; ADRA2C; ADRA2A; CNR2;
Peptide receptor (family A GPCR)	TSHR; NMUR2;
Hydrolase	GAA; ACHE;
Enzyme_unclassified	GLA; ALOX15; PTPRCAP; POLB;
Protein Kinase	MAPK1;
Lyase	CA2; CA12; CA9; CA3; CA4;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Nuclear hormone receptor subfamily 2 group B	RXRA;
Oxidoreductase	ALOX5; XDH;
Cysteine protease	CASP1; CASP7;
Metallo protease	MMP2;
Toll-like and Il-1 receptors	TLR2;
Transcription Factor	HIF1A;
Unclassified	RAB9A; LMNA; FABP3; FABP5; FABP2; FABP4; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	GLA	Alpha-galactosidase A	P06280	CHEMBL2524
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	PTPRCAP	Protein tyrosine phosphatase receptor type C-associated protein	Q14761	CHEMBL4806
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 2 group B	RXRA	Retinoid X receptor alpha	P19793	CHEMBL2061
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NMUR2	Neuromedin-U receptor 2	Q9GZQ4	CHEMBL1075144
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	CNR1	Cannabinoid CB1 receptor	P21554	CHEMBL218
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867
Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.988E-11	5.430E-07	CA12, CA2, CA3, CA4, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	6.088E-09	1.105E-05	CA12, CA2, CA3, CA4, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.735E-08	2.699E-05	CA12, CA2, CA3, CA4, CA9
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	1.250E-07	1.361E-04	FABP2, FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0051001; negative regulation of nitric-oxide synthase activity	2.070E-07	1.960E-04	CNR1, CNR2, GLA
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	4.304E-07	3.347E-04	CASP1, HIF1A, LMNA, MMP2, PPARA, PPARD, TLR2
BP	GO:0050896; response to stimulus	GO:0010243; response to organonitrogen compound	8.612E-07	5.705E-04	CASP1, CASP7, CNR1, CNR2, FABP3, MAPK1, MMP2, PPARA, TLR2, TSHR
BP	GO:0050896; response to stimulus	GO:0033993; response to lipid	5.149E-06	2.116E-03	CA2, CA9, CASP1, CNR1, CNR2, FABP3, PPARD, RXRA, TLR2
BP	GO:0050896; response to stimulus	GO:0042493; response to drug	6.084E-06	2.366E-03	CA3, CA9, CASP1, CNR1, CNR2, FABP3, MAPK1, POLB, TLR2
BP	GO:0050896; response to stimulus	GO:0050727; regulation of inflammatory response	6.313E-06	2.411E-03	CASP1, CNR1, CNR2, FABP4, PPARA, PPARD, TLR2
BP	GO:0051179; localization	GO:0015908; fatty acid transport	7.162E-06	2.643E-03	FABP3, NMUR2, PPARA, PPARD
MF	GO:0060089; molecular transducer activity	GO:0004949; cannabinoid receptor activity	1.012E-05	3.355E-03	CNR1, CNR2
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	1.012E-05	3.355E-03	ADRA2A, ADRA2C
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.340E-05	4.229E-03	CA12, CA2, CA3, CA4, CA9, MMP2, PPARA, PPARD, RXRA
BP	GO:0023052; signaling	GO:0050796; regulation of insulin secretion	1.592E-05	4.914E-03	ADRA2A, ADRA2C, CNR1, HIF1A, PPARD
BP	GO:0065007; biological regulation	GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process	1.602E-05	4.914E-03	CASP1, CASP7, MAPT, XDH
BP	GO:0032501; multicellular organismal process	GO:0001816; cytokine production	1.681E-05	5.015E-03	CASP1, FABP4, HIF1A, TLR2
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	2.022E-05	5.655E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	2.022E-05	5.655E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0038171; cannabinoid signaling pathway	2.022E-05	5.655E-03	CNR1, CNR2
CC	GO:0016020; membrane	GO:0005886; plasma membrane	2.089E-05	5.697E-03	ACHE, ADRA2A, ADRA2C, ALOX15, CA12, CA2, CA4, CA9, CNR1, CNR2, FABP5, GAA, MAPK1, MAPT, MMP2, NMUR2, PTPRCAP, RAB9A, TLR2, TSHR
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	2.321E-05	6.090E-03	ADRA2A, CA2, CA4, CA9, TSHR
BP	GO:0008152; metabolic process	GO:0006691; leukotriene metabolic process	2.578E-05	6.605E-03	ALOX15, ALOX5, TLR2
BP	GO:0023052; signaling	GO:0032228; regulation of synaptic transmission, GABAergic	2.841E-05	7.194E-03	CA2, CNR1, CNR2
MF	GO:0005488; binding	GO:0051379; epinephrine binding	9.390E-05	1.733E-02	ADRA2A, ADRA2C
CC	GO:0044464; cell part	GO:0030424; axon	1.079E-04	1.895E-02	ADRA2C, CA2, CNR1, MAPK1, MAPT
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	2.624E-04	3.421E-02	HIF1A, MAPK1, MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	3.281E-11	4.626E-09	FABP2, FABP3, RXRA, FABP4, FABP5, PPARA, PPARD
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.618E-11	6.076E-09	CA12, CA3, CA2, CA4, CA9
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9.185E-06	4.317E-04	CNR2, CNR1, NMUR2, ADRA2C, ADRA2A, TSHR
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.318E-04	4.644E-03	CASP7, CASP1, TLR2
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	4.706E-04	9.480E-03	MMP2, MAPK1, HIF1A, TLR2
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	6.825E-04	1.203E-02	RXRA, MMP2, MAPK1, HIF1A, PPARD
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.814E-04	7.775E-03	RXRA, CA2, CYP3A4
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	3.308E-04	7.775E-03	CASP7, CASP1, MAPK1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	7.783E-04	1.219E-02	CA2, CA4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.240E-03	1.248E-02	ALOX15, CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CNR2; ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
C00-D49: Neoplasms	Solid tumours	C00-D48	MMP2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CNR2;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	CNR2;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	CNR2;
C00-D49: Neoplasms	Cutaneous T-cell lymphoma	C84.0, C84.1	RXRA;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	CNR2;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	CNR2;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE; MMP2;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	CNR2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Immune disorder	D80-D89	CNR2;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
NA: NA	Upper abdominal bloating	NA	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases