CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA1; ADORA2A;
Peptide receptor (family A GPCR)	NPSR1;
Protein Kinase	MET; FLT3; CDK1; PIM1; AXL; KDR; IGF1R; AURKB;
Enzyme_unclassified	PIK3CA; PIK3CB; ADK; ALOX12; GFER; HSD17B10; NQO2; NOX4; POLB;
Lyase	CA2; CA1; CA12; CA9; CA14; CA7;
Nuclear hormone receptor subfamily 3 group A	ESR1;
Oxidoreductase	PTGS1; PTGS2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP1B1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	PIK3CA	PI3-kinase p110-alpha subunit	P42336	CHEMBL4005
Enzyme_unclassified	PIK3CB	PI3-kinase p110-beta subunit	P42338	CHEMBL3145
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NQO2	Quinone reductase 2	P16083	CHEMBL3959
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375

Showing 1 to 10 of 32 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	8.493E-11	3.511E-07	CA1, CA12, CA14, CA2, CA7, CA9
BP	GO:0050896; response to stimulus	GO:0006954; inflammatory response	1.254E-09	2.730E-06	ADORA1, ADORA2A, ADORA3, AXL, NOX4, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.269E-09	5.476E-06	CA1, CA12, CA2, CA7, CA9
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	6.740E-08	6.252E-05	ADORA1, ADORA2A, ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, PIK3CA, PIM1, PTGS2
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	3.446E-07	2.274E-04	ADORA1, ADORA2A, ADORA3
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	1.041E-06	5.460E-04	ADORA1, ADORA2A, CA2, CA7, KDR, NPSR1
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	1.168E-06	5.780E-04	ADORA2A, CA2, CA7
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	4.792E-06	1.630E-03	AXL, MET, NOX4, PIK3CA, PIK3CB
BP	GO:0009987; cellular process	GO:0048010; vascular endothelial growth factor receptor signaling pathway	5.896E-06	1.945E-03	AXL, KDR, PIK3CA, PIK3CB
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	7.968E-06	2.508E-03	CA2, CA7

Showing 1 to 10 of 27 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.247E-13	1.547E-11	CA12, CA1, CA2, CA7, CA9, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.320E-04	9.857E-04	ALOX12, PTGS2, PTGS1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3.877E-03	9.811E-03	CYP1B1, CYP3A4
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	9.256E-07	2.869E-05	PIK3CA, ADORA2A, KDR, PIK3CB, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	2.641E-06	5.459E-05	PIK3CA, KDR, PIK3CB, PTGS2
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	2.827E-05	3.186E-04	PIK3CA, KDR, PIK3CB, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	3.892E-05	3.712E-04	PIK3CA, ADORA3, ADORA1, PIK3CB
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	1.405E-04	9.857E-04	PIK3CA, ADORA3, ADORA1, PIK3CB
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	1.930E-04	1.139E-03	PIK3CA, KDR, PIK3CB, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	2.749E-04	1.420E-03	PIK3CA, ADORA2A, ADORA1, PIK3CB

Showing 1 to 10 of 49 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Renal cancer	C64	KDR; CA9;
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Ageratina adenophora

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities