Plant Name: Drosera spatulata
Taxonomic Information:
Plant ID: NPO11698
Plant Latin Name: Drosera spatulata
Taxonomy Genus: Drosera
Taxonomy Family: Droseraceae
Plant External Links:
NCBI TaxonomyDB:
16681
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| PIM1; AURKB; AURKA; KDR; | |
| GFER; | |
| RAB9A; NPC1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Enzyme_unclassified | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
| Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
| Protein Kinase | AURKA | Serine/threonine-protein kinase Aurora-A | O14965 | CHEMBL4722 |
| Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0046777; protein autophosphorylation | 1.245E-06 | 2.099E-02 | AURKA, AURKB, KDR, PIM1 |
| CC | GO:0032991; macromolecular complex | GO:0032133; chromosome passenger complex | 1.928E-06 | 2.099E-02 | AURKA, AURKB |
| MF | GO:0003824; catalytic activity | GO:0035174; histone serine kinase activity | 2.892E-06 | 2.099E-02 | AURKA, AURKB |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 8.667E-06 | 3.909E-02 | CYP1A1, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:0035404; histone-serine phosphorylation | 1.271E-05 | 3.909E-02 | AURKA, AURKB |
| CC | GO:0043226; organelle | GO:0000780; condensed nuclear chromosome, centromeric region | 1.271E-05 | 3.909E-02 | AURKA, AURKB |
| CC | GO:0043226; organelle | GO:0031616; spindle pole centrosome | 1.271E-05 | 3.909E-02 | AURKA, AURKB |
| BP | GO:0009987; cellular process | GO:0060548; negative regulation of cell death | 3.102E-05 | 5.254E-02 | AURKA, AURKB, KDR, NPC1, PIM1 |
| MF | GO:0005488; binding | GO:0008144; drug binding | 3.378E-05 | 5.254E-02 | AURKA, AURKB, CYP1A1, CYP1B1, KDR, PIM1 |
| BP | GO:0050896; response to stimulus | GO:0010035; response to inorganic substance | 3.700E-05 | 5.371E-02 | CYP1A1, CYP1B1, KDR, NPC1 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 4.034E-05 | 5.490E-02 | CYP1A1, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 4.858E-05 | 5.877E-02 | CYP1A1, CYP1B1 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 4.858E-05 | 5.877E-02 | CYP1A1, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:1903409; reactive oxygen species biosynthetic process | 5.298E-05 | 6.072E-02 | CYP1A1, CYP1B1 |
| CC | GO:0043226; organelle | GO:0051233; spindle midzone | 8.911E-05 | 8.436E-02 | AURKA, AURKB |
| MF | GO:0005488; binding | GO:0000166; nucleotide binding | 1.035E-04 | 9.038E-02 | AURKA, AURKB, GFER, KDR, PIM1, RAB9A |
| CC | GO:0043226; organelle | GO:0005876; spindle microtubule | 2.627E-04 | 1.631E-01 | AURKA, AURKB |
| CC | GO:0043226; organelle | GO:0043231; intracellular membrane-bounded organelle | 2.870E-04 | 1.631E-01 | AURKA, AURKB, CYP1A1, CYP1B1, GFER, KDR, NPC1, PIM1, RAB9A |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 1.392E-04 | 2.154E-03 | CYP1A1, CYP1B1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 2.181E-04 | 2.154E-03 | CYP1A1, CYP1B1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 2.937E-04 | 2.154E-03 | CYP1A1, CYP1B1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 4.653E-04 | 2.559E-03 | CYP1A1, CYP1B1 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 5.867E-04 | 2.582E-03 | CYP1A1, CYP1B1 |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 7.385E-03 | 2.708E-02 | PIM1, CYP1B1 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 2.536E-02 | 7.059E-02 | PIM1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04370 | VEGF signaling pathway | 2.712E-02 | 7.059E-02 | KDR |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 4.455E-02 | 9.801E-02 | PIM1 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 2.888E-02 | 7.059E-02 | CYP1A1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Gastric cancer | C16 | KDR; |
| C00-D49: Neoplasms | Peritoneal cavity cancer | NA | KDR; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | AURKA; AURKB; |
| C00-D49: Neoplasms | Glioma | C71 | KDR; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | KDR; |
| C00-D49: Neoplasms | Breast cancer | C50 | KDR; |
| C00-D49: Neoplasms | Gastrointestinal cancers | C15-C26 | KDR; |
| C00-D49: Neoplasms | Ovarian cancer | C56 | KDR; |
| C00-D49: Neoplasms | Cutaneous Melanoma | C43-C44 | KDR; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | KDR; |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | AURKA; |
| C00-D49: Neoplasms | Haematological malignancies | C81-C86 | AURKA; |
| C00-D49: Neoplasms | AML | NA | KDR; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | KDR; |
| C00-D49: Neoplasms | Non-small-cell lung cancer | NA | KDR; |
| C00-D49: Neoplasms | Squamous cell cancer of head and neck | NA | KDR; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | AURKA; AURKB; KDR; |
| C00-D49: Neoplasms | Melanoma | C43 | KDR; |
| C00-D49: Neoplasms | Medullary thyroid cancer | C73 | KDR; |
| C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | KDR; |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | KDR; |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | KDR; |
| C00-D49: Neoplasms | Biliary cancer | C22, C24 | KDR; |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | KDR; |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | KDR; |
| C00-D49: Neoplasms | Advanced renal cell carcinoma | C64 | KDR; |
| C00-D49: Neoplasms | Cancer | C00-C96 | AURKA; KDR; |
| C00-D49: Neoplasms | Renal cell carcinoma | NA | KDR; |
| C00-D49: Neoplasms | Renal cancer | C64 | KDR; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | AURKA; |
| C00-D49: Neoplasms | Liver cancer | C22 | KDR; |
| C00-D49: Neoplasms | Fallopian tube cancer | C57.0, D28.2 | KDR; |
| I00-I99: Diseases of the circulatory system | Angiogenesis disorder | I00-I99 | KDR; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | KDR; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | AURKB; |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | KDR; |
| C00-D49: Neoplasms | Thyroid cancer | C73 | KDR; |
| C00-D49: Neoplasms | Advanced malignancies | C00-C96 | KDR; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
