CMAUP Plant Collective Molecular Activities

Plant Name: Asparagus cochinchinensis

Taxonomic Information:

Plant ID: NPO11694
Plant Latin Name: Asparagus cochinchinensis
Taxonomy Genus: Asparagus
Taxonomy Family: Asparagaceae

Plant External Links:

NCBI TaxonomyDB: 100514
Plant-of-the-World-Online: 531041-1

Used in Medicines:

Country/Region:

Indonesia

Traditional Medicine System:

Medicinal Functions:

Antibacterial; Antiinflammatory; Antipyretic; Antiseptic; Antitussive; Cancer; Diuretic; Expectorant; Infertility; Nervine; Sialagogue; Stomachic; Tonic

Geographical Distribution:

South Africa; Philippines; Indonesia; Cambodia; Vietnam; China; Laos; Japan; Taiwan

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	8.787E-07	1.913E-02	SLCO1B1, SLCO1B3, TSHR
MF	GO:0005215; transporter activity	GO:0015125; bile acid transmembrane transporter activity	2.459E-06	2.677E-02	SLCO1B1, SLCO1B3
BP	GO:0051179; localization	GO:0043252; sodium-independent organic anion transport	6.074E-06	3.044E-02	SLCO1B1, SLCO1B3
BP	GO:0051179; localization	GO:0015721; bile acid and bile salt transport	6.989E-06	3.044E-02	SLCO1B1, SLCO1B3
MF	GO:0005215; transporter activity	GO:0015347; sodium-independent organic anion transmembrane transporter activity	4.435E-06	3.044E-02	SLCO1B1, SLCO1B3
BP	GO:0009987; cellular process	GO:0038194; thyroid-stimulating hormone signaling pathway	3.106E-04	3.757E-01	TSHR
MF	GO:0060089; molecular transducer activity	GO:0004996; thyroid-stimulating hormone receptor activity	3.106E-04	3.757E-01	TSHR
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	3.874E-04	4.301E-01	SLCO1B1, SLCO1B3, TSHR
CC	GO:0032991; macromolecular complex	GO:0043235; receptor complex	4.918E-02	1.000E+00	TSHR

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.719E-05	2.231E-04	SLCO1B1, SLCO1B3
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	7.929E-03	1.592E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8.377E-03	1.592E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	1.061E-02	1.592E-02	TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	2.956E-02	3.547E-02	TSHR
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	4.098E-02	4.098E-02	TSHR

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases