CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	TDP1; PYGL; AGL;
Unclassified	HTT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	PYGL	Liver glycogen phosphorylase	P06737	CHEMBL2568
Enzyme_unclassified	AGL	Glycogen debranching enzyme	P35573	CHEMBL5272
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514

Showing 1 to 5 of 5 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
CC	GO:0044464; cell part	GO:0005770; late endosome	3.446E-02	1.000E+00	HTT
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	4.723E-02	1.000E+00	TSHR
MF	GO:0060089; molecular transducer activity	GO:0004996; thyroid-stimulating hormone receptor activity	5.177E-04	3.887E-01	TSHR

Showing 1 to 3 of 3 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	7.659E-05	8.425E-04	AGL, PYGL
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	4.877E-02	5.365E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.392E-02	4.713E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	1.763E-02	4.713E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04922	Glucagon signaling pathway	2.500E-02	4.713E-02	PYGL
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	3.427E-02	4.713E-02	PYGL
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	1.318E-02	4.713E-02	TSHR
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	2.696E-02	4.713E-02	PYGL
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05016	Huntington's disease	4.733E-02	5.365E-02	HTT
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.382E-02	4.713E-02	AGL, PYGL

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Stellaria dichotoma

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities