CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	PIK3CA; PIK3CB; GFER; NQO2;
Lyase	CA2; CA1; CA12; CA9; CA13; CA5B; CA3; CA14; CA5A; CA4; CA6; CA7;
Nuclear hormone receptor subfamily 3 group A	ESR1;
Oxidoreductase	PTGS1; MAOA; PTGS2;
Transcription Factor	HIF1A; TP53;
SLC superfamily of solute carriers	SLC6A2;
Unclassified	HTT; APP;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP3A4; CYP1A2;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	NQO2	Quinone reductase 2	P16083	CHEMBL3959
Enzyme_unclassified	PIK3CA	PI3-kinase p110-alpha subunit	P42336	CHEMBL4005
Enzyme_unclassified	PIK3CB	PI3-kinase p110-beta subunit	P42338	CHEMBL3145
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	6.131E-11	1.027E-07	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	2.011E-09	2.737E-06	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.574E-08	1.653E-05	CYP1A2, CYP2C19, CYP2C9, CYP3A4, NQO2, PTGS1
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.625E-07	2.442E-04	CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	6.633E-07	3.801E-04	CYP1A2, CYP2C9, CYP3A4
BP	GO:0065007; biological regulation	GO:0030003; cellular cation homeostasis	1.306E-06	6.772E-04	APP, CA2, CA7, ESR1, HIF1A, HTT, PIK3CB, TP53
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.527E-06	7.559E-04	APP, CYP1A2, CYP2C19, CYP2C9, CYP3A4, ESR1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.900E-25	2.069E-21	CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.974E-06	1.766E-03	CYP1A2, CYP2C19, CYP2C9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.523E-06	2.732E-03	CA2, CA7

Showing 1 to 10 of 19 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.753E-32	4.541E-30	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14, CA13
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4.697E-08	1.894E-06	CYP2C9, MAOA, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	8.255E-08	2.497E-06	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.876E-06	2.837E-05	CYP2C9, CYP2C19, PTGS2, PTGS1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.127E-04	7.136E-04	CYP2C9, CYP1A2, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.592E-04	8.028E-04	CYP2C9, CYP1A2, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3.191E-03	7.880E-03	CYP1A2, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.530E-03	4.409E-03	MAOA, CYP1A2
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	8.872E-05	7.136E-04	PIK3CA, PIK3CB, HIF1A
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	9.322E-05	7.136E-04	PIK3CA, PIK3CB, PTGS2

Showing 1 to 10 of 50 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
C00-D49: Neoplasms	Solid tumours	C00-D48	PIK3CA; PIK3CB; CA9;
C00-D49: Neoplasms	Cancer	C00-C96	ESR1; PIK3CA; PTGS2; PIK3CB; NQO2; CA9;
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Breast cancer	C50	ESR1; NQO2; CA9;
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1;
C00-D49: Neoplasms	Prostate cancer	C61	ESR1;
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	PTGS2;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Curcuma xanthorrhiza

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities