Plant Name: Primula viscosa
Taxonomic Information:
Plant ID: NPO11489
Plant Latin Name: Primula viscosa
Taxonomy Genus: Primula
Taxonomy Family: Primulaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| MAPK1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP3A4; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019858; cytosine metabolic process | 2.071E-04 | 4.509E-01 | MAPK1 |
| BP | GO:0008152; metabolic process | GO:0009822; alkaloid catabolic process | 3.106E-04 | 4.509E-01 | CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0070576; vitamin D 24-hydroxylase activity | 3.106E-04 | 4.509E-01 | CYP3A4 |
| BP | GO:0051179; localization | GO:0072584; caveolin-mediated endocytosis | 5.177E-04 | 4.697E-01 | MAPK1 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 4.141E-04 | 4.697E-01 | CYP3A4 |
| CC | Unclassified; | GO:0031143; pseudopodium | 1.759E-03 | 7.095E-01 | MAPK1 |
| CC | GO:0044464; cell part | GO:0032839; dendrite cytoplasm | 2.587E-03 | 8.744E-01 | MAPK1 |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 6.925E-03 | 1.000E+00 | MAPK1 |
| CC | GO:0016020; membrane | GO:0005901; caveola | 7.338E-03 | 1.000E+00 | MAPK1 |
| CC | GO:0044464; cell part | GO:0035578; azurophil granule lumen | 9.400E-03 | 1.000E+00 | MAPK1 |
| CC | GO:0044464; cell part | GO:0043204; perikaryon | 1.187E-02 | 1.000E+00 | MAPK1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 2.898E-03 | 1.792E-02 | MAPK1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 2.898E-03 | 1.792E-02 | CYP3A4 |
| Unclassified | Unclassified | hsa04320 | Dorso-ventral axis formation | 2.698E-03 | 1.792E-02 | MAPK1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05020 | Prion diseases | 3.497E-03 | 1.792E-02 | MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05223 | Non-small cell lung cancer | 5.592E-03 | 1.792E-02 | MAPK1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04730 | Long-term depression | 5.991E-03 | 1.792E-02 | MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 6.490E-03 | 1.792E-02 | MAPK1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04150 | mTOR signaling pathway | 5.991E-03 | 1.792E-02 | MAPK1 |
| 09150 Organismal Systems | 09159 Environmental adaptation | hsa04713 | Circadian entrainment | 9.478E-03 | 1.792E-02 | MAPK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 7.486E-03 | 1.792E-02 | MAPK1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
