CMAUP Plant Collective Molecular Activities

Plant Name: Ligusticum jeholense

Taxonomic Information:

Plant ID: NPO11474
Plant Latin Name: Ligusticum jeholense
Taxonomy Genus: Ligusticum
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 49553
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Analgesic; Antifungal; Antirheumatic; Antispasmodic; Diaphoretic

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Hydrolase	ACHE;
Lyase	CA2; CA12; CA1; CA9; CA14; CA7; CA5A; CA6;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Enzyme_unclassified	HPGD; ALOX15;
Transcription Factor	NFKB1;
Unclassified	LMNA; FABP3;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP3A4; CYP2A6; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.744E-11	5.432E-08	CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	5.157E-10	7.486E-07	CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	9.011E-10	1.226E-06	CYP2A6, CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.893E-08	1.718E-05	CA1, CA12, CA2, CA5A, CA6, CA7, CA9, PPARA, PPARD, PPARG
MF	GO:0005488; binding	GO:0005506; iron ion binding	3.498E-08	2.539E-05	ALOX15, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	2.661E-07	1.436E-04	FFAR4, NFKB1, PPARA, PPARD, PPARG
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.639E-07	1.436E-04	CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	3.681E-07	1.864E-04	CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	4.566E-07	2.161E-04	CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, PPARD
MF	GO:0005488; binding	GO:0020037; heme binding	4.539E-07	2.161E-04	CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	8.063E-07	3.583E-04	CA2, CA9, FABP3, FFAR4, HPGD, NFKB1, PPARA, PPARG
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	1.133E-06	4.744E-04	CYP2A6, CYP2C19, CYP2C9
BP	GO:0051179; localization	GO:0015908; fatty acid transport	1.333E-06	5.278E-04	FABP3, PPARA, PPARD, PPARG
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	2.209E-06	8.292E-04	CYP2A6, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	4.435E-06	1.583E-03	CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.435E-06	1.583E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0016712; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	4.300E-06	1.583E-03	CYP2A6, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	8.864E-06	2.924E-03	CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.116E-05	3.574E-03	CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	1.476E-05	4.464E-03	PPARA, PPARG
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	2.213E-05	5.805E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	2.213E-05	5.805E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	2.213E-05	5.805E-03	ALOX15, HPGD
MF	GO:0005488; binding	GO:0050543; icosatetraenoic acid binding	2.213E-05	5.805E-03	FABP3, PPARG
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.213E-05	5.805E-03	CA1, CA2
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	2.921E-05	7.482E-03	ACHE, CYP3A4, FFAR1, FFAR4, NFKB1, PPARD
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	2.991E-05	7.485E-03	PPARA, PPARD, PPARG
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	3.095E-05	7.489E-03	CYP2A6, CYP2D6
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.810E-21	2.136E-16	CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.645E-16	2.880E-12	CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.421E-14	5.156E-11	CA1, CA12, CA2, CA5A, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.802E-20	2.270E-18	CA12, CA1, CA2, CA5A, CA7, CA6, CA9, CA14
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.704E-08	6.899E-07	CYP2C9, CYP2A6, CYP2D6, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.712E-08	1.002E-06	CYP2C9, ALOX15, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.642E-06	2.660E-05	CYP2C9, CYP2A6, CYP2D6, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.308E-06	2.650E-05	FABP3, PPARG, PPARA, PPARD
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	9.082E-06	1.051E-04	CYP2C9, CYP2D6, ALOX15, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.620E-06	3.537E-05	CYP2C9, CYP2A6, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	5.481E-05	5.550E-04	CYP2C9, ALOX15, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6.316E-05	5.684E-04	CYP2C9, CYP2A6, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	1.263E-03	1.018E-02	HPGD, PPARG, NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases