Plant Name: Barbacenia flava
Taxonomic Information:
Plant ID: NPO11441
Plant Latin Name: Barbacenia flava
Taxonomy Genus: Barbacenia
Taxonomy Family: Velloziaceae
Plant External Links:
NCBI TaxonomyDB:
1051457
Plant-of-the-World-Online:
63160-1
Used in Medicines:
Unknown.
Geographical Distribution:
Brazil
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| PTPN1; | |
| NR1H4; | |
| AKR1B1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 1.888E-05 | 1.409E-01 | NR1H4, PTPN1 |
| BP | GO:0009987; cellular process | GO:0043066; negative regulation of apoptotic process | 8.704E-05 | 1.409E-01 | AKR1B1, NR1H4, PTPN1 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 4.659E-04 | 2.321E-01 | NR1H4 |
| CC | GO:0044464; cell part | GO:0097443; sorting endosome | 9.316E-04 | 3.170E-01 | PTPN1 |
| MF | GO:0060089; molecular transducer activity | GO:0004887; thyroid hormone receptor activity | 1.087E-03 | 3.381E-01 | NR1H4 |
| MF | GO:0005488; binding | GO:0046965; retinoid X receptor binding | 2.328E-03 | 4.608E-01 | NR1H4 |
| MF | GO:0005488; binding | GO:0016922; ligand-dependent nuclear receptor binding | 3.258E-03 | 5.500E-01 | NR1H4 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 5.391E-03 | 1.617E-02 | AKR1B1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 4.493E-03 | 1.617E-02 | AKR1B1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00561 | Glycerolipid metabolism | 8.824E-03 | 1.659E-02 | AKR1B1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 4.793E-03 | 1.617E-02 | AKR1B1 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 1.106E-02 | 1.659E-02 | PTPN1 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.061E-02 | 1.659E-02 | NR1H4 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 1.626E-02 | 2.091E-02 | PTPN1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04910 | Insulin signaling pathway | 2.071E-02 | 2.329E-02 | PTPN1 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 1.746E-01 | 1.746E-01 | AKR1B1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
