CMAUP Plant Collective Molecular Activities

Plant Name: Alluaudia ascendens

Plant ID: NPO11437
Plant Latin Name: Alluaudia ascendens
Taxonomy Genus: Alluaudia
Taxonomy Family: Didiereaceae

NCBI TaxonomyDB: 46152
Plant-of-the-World-Online: n.a.

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPR35;
Peptide receptor (family A GPCR)	OPRD1;
Enzyme_unclassified	AMY1A;AMY1B;AMY1C; GFER;
Protein Phosphatase	PTPRS;
Protein Kinase	PIM1; KIT; GRK6;
Transcription Factor	TP53;
Unclassified	RAB9A; NPC1;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1;

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	AMY1A;AMY1B;AMY1C	Salivary alpha-amylase	P04745	CHEMBL2478
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KIT	Stem cell growth factor receptor	P10721	CHEMBL1936
Protein Kinase	GRK6	G protein-coupled receptor kinase 6	P43250	CHEMBL6144
Protein Phosphatase	PTPRS	Receptor-type tyrosine-protein phosphatase S	Q13332	CHEMBL2396508
Small molecule receptor (family A GPCR)	GPR35	G-protein coupled receptor 35	Q9HC97	CHEMBL1293267
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004556; alpha-amylase activity	5.656E-09	6.158E-05	AMY1A, AMY1B, AMY1C
MF	Unclassified;	GO:0103025; alpha-amylase activity (releasing maltohexaose)	5.656E-09	6.158E-05	AMY1A, AMY1B, AMY1C

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1.375E-05	4.263E-04	AMY1A, AMY1B, AMY1C
09150 Organismal Systems	09154 Digestive system	hsa04973	Carbohydrate digestion and absorption	7.080E-06	4.263E-04	AMY1A, AMY1B, AMY1C
09150 Organismal Systems	09154 Digestive system	hsa04970	Salivary secretion	5.537E-05	1.144E-03	AMY1A, AMY1B, AMY1C
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	5.204E-04	8.067E-03	CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	8.133E-04	9.681E-03	CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.056E-03	9.681E-03	KIT, PIM1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.455E-03	1.128E-02	KIT, TP53
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.889E-03	1.171E-02	PIM1, CYP1B1, TP53
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.093E-03	9.681E-03	CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.725E-03	1.171E-02	CYP1A1, CYP1B1

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases