CMAUP Plant Collective Molecular Activities

Plant Name: Echinops grijsii

Taxonomic Information:

Plant ID: NPO11329
Plant Latin Name: Echinops grijsii
Taxonomy Genus: Echinops
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 1804979
Plant-of-the-World-Online: 202515-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

Taiwan; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Nuclear hormone receptor subfamily 1 group C	PPARD; PPARA; PPARG;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	ALOX15; HPGD;
Toll-like and Il-1 receptors	TLR2;
Unclassified	FABP3; FABP2; FABP4; LMNA; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	2.087E-09	5.238E-06	FABP3, FFAR1, NR1H4, PPARG, TLR2
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	2.165E-09	5.238E-06	FABP2, FABP3, FABP4, FABP5
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	1.314E-08	1.908E-05	FFAR4, NR1H4, PPARA, PPARD, PPARG
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	3.590E-08	3.445E-05	NR1H4, PPARA, PPARD, PPARG
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	7.680E-08	6.471E-05	NR1H4, PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0015908; fatty acid transport	1.289E-07	9.356E-05	FABP3, PPARA, PPARD, PPARG
BP	GO:0065007; biological regulation	GO:0055088; lipid homeostasis	9.537E-07	5.192E-04	FABP3, FABP4, NR1H4, PPARG
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	1.861E-06	8.442E-04	NR1H4, PPARA, PPARD, PPARG
BP	GO:0050896; response to stimulus	GO:0032868; response to insulin	2.431E-06	9.986E-04	FABP3, PPARA, PPARG, TLR2
MF	Unclassified;	GO:0004872; receptor activity	3.348E-06	1.326E-03	FFAR1, FFAR4, HPGD, NR1H4, PPARA, PPARD, PPARG, TLR2
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	4.254E-06	1.597E-03	NR1H4, PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	4.872E-06	1.768E-03	PPARA, PPARG
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	6.070E-06	2.132E-03	NR1H4, PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	7.305E-06	2.272E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	7.305E-06	2.272E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	7.305E-06	2.272E-03	ALOX15, HPGD
MF	GO:0005488; binding	GO:0050543; icosatetraenoic acid binding	7.305E-06	2.272E-03	FABP3, PPARG
BP	GO:0023052; signaling	GO:0032024; positive regulation of insulin secretion	1.477E-05	3.876E-03	FFAR1, NR1H4, PPARD
BP	GO:0008152; metabolic process	GO:0071073; positive regulation of phospholipid biosynthetic process	1.751E-05	4.486E-03	FABP3, NR1H4
BP	GO:0050896; response to stimulus	GO:0042060; wound healing	2.148E-05	5.315E-03	ALOX15, PPARA, PPARD
MF	GO:0060089; molecular transducer activity	GO:0004955; prostaglandin receptor activity	2.188E-05	5.353E-03	HPGD, PPARG
BP	GO:0008152; metabolic process	GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter	2.673E-05	6.134E-03	PPARA, PPARD
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	2.844E-05	6.323E-03	LMNA, PPARA, PPARD, TLR2
BP	GO:0009987; cellular process	GO:0050872; white fat cell differentiation	3.788E-05	7.708E-03	FABP4, PPARG
BP	GO:0009987; cellular process	GO:0010745; negative regulation of macrophage derived foam cell differentiation	3.788E-05	7.708E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0046321; positive regulation of fatty acid oxidation	4.417E-05	8.824E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0032966; negative regulation of collagen biosynthetic process	4.417E-05	8.824E-03	PPARD, PPARG
MF	GO:0005488; binding	GO:0046965; retinoid X receptor binding	5.095E-05	9.725E-03	NR1H4, PPARG

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.432E-14	6.301E-13	FABP2, FABP3, FABP4, FABP5, PPARG, PPARA, PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3.851E-02	1.220E-01	FABP4
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	3.783E-02	1.220E-01	TLR2
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	4.255E-02	1.220E-01	ALOX15
09160 Human Diseases	09162 Immune diseases	hsa05321	Inflammatory bowel disease (IBD)	4.457E-02	1.220E-01	TLR2
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	4.792E-02	1.220E-01	PPARA
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	4.992E-02	1.220E-01	TLR2
09150 Organismal Systems	09158 Development	hsa04380	Osteoclast differentiation	8.857E-02	1.220E-01	PPARG
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	9.369E-02	1.220E-01	LMNA
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	8.921E-02	1.220E-01	PPARA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases