Plant Name: Juniperus chinensis
Taxonomic Information:
Plant ID: NPO11328
Plant Latin Name: Juniperus chinensis
Taxonomy Genus: Juniperus
Taxonomy Family: Cupressaceae
Plant External Links:
NCBI TaxonomyDB:
50182
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Unknown.
Geographical Distribution:
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| ALOX12; AKR1B1; ALOX15; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 3.216E-08 | 1.751E-04 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 3.216E-08 | 1.751E-04 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 9.649E-08 | 3.502E-04 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 9.649E-08 | 3.502E-04 | ALOX12, ALOX15 |
| BP | GO:0008152; metabolic process | GO:0051122; hepoxilin biosynthetic process | 3.216E-07 | 8.753E-04 | ALOX12, ALOX15 |
| BP | GO:0008152; metabolic process | GO:0019372; lipoxygenase pathway | 3.856E-06 | 5.997E-03 | ALOX12, ALOX15 |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 3.797E-02 | 1.000E+00 | TSHR |
| CC | GO:0016020; membrane | GO:0005886; plasma membrane | 3.923E-02 | 1.000E+00 | ALOX12, ALOX15, TSHR |
| CC | GO:0044425; membrane part | GO:0019898; extrinsic component of membrane | 3.998E-02 | 1.000E+00 | ALOX15 |
| CC | GO:0044464; cell part | GO:0099568; cytoplasmic region | 4.158E-02 | 1.000E+00 | AKR1B1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 5.651E-05 | 7.911E-04 | ALOX15, ALOX12 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.851E-04 | 1.296E-03 | ALOX15, ALOX12 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 9.049E-04 | 4.223E-03 | ALOX15, AKR1B1, ALOX12 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 5.788E-03 | 1.436E-02 | ALOX15 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 7.181E-03 | 1.436E-02 | AKR1B1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 5.987E-03 | 1.436E-02 | AKR1B1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 1.115E-02 | 1.645E-02 | TSHR |
| 09160 Human Diseases | 09162 Immune diseases | hsa05320 | Autoimmune thyroid disease | 1.056E-02 | 1.645E-02 | TSHR |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00561 | Glycerolipid metabolism | 1.175E-02 | 1.645E-02 | AKR1B1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 6.385E-03 | 1.436E-02 | AKR1B1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
