CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HTR2C; DRD3;
Peptide receptor (family A GPCR)	OPRD1;
Protein Phosphatase	PTPN1; PTPN2;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Aspartic protease	BACE1;
Endoplasmic reticular retrotranslocon family	VCP;
Unclassified	MCL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Endoplasmic reticular retrotranslocon family	VCP	Transitional endoplasmic reticulum ATPase	P55072	CHEMBL1075145
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Small molecule receptor (family A GPCR)	HTR2C	Serotonin 2c (5-HT2c) receptor	P28335	CHEMBL225
Small molecule receptor (family A GPCR)	DRD3	Dopamine D3 receptor	P35462	CHEMBL234
Unclassified	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361

Showing 1 to 9 of 9 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	1.157E-06	6.765E-03	PTPN1, PTPN2
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	1.275E-06	6.765E-03	NR1H4, PTPN1, PTPN2
BP	GO:0009987; cellular process	GO:1902532; negative regulation of intracellular signal transduction	1.553E-06	6.765E-03	DRD3, MCL1, NR1H4, PTPN1, PTPN2
BP	GO:0008152; metabolic process	GO:0071073; positive regulation of phospholipid biosynthetic process	6.936E-06	2.157E-02	HTR2C, NR1H4
BP	GO:0009987; cellular process	GO:1903897; regulation of PERK-mediated unfolded protein response	8.667E-06	2.359E-02	PTPN1, PTPN2
BP	GO:0009987; cellular process	GO:1900103; positive regulation of endoplasmic reticulum unfolded protein response	1.501E-05	3.468E-02	PTPN1, PTPN2
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	2.637E-03	2.599E-01	BACE1, DRD3, HTR2C, OPRD1
CC	GO:0032991; macromolecular complex	GO:0097136; Bcl-2 family protein complex	2.793E-03	2.599E-01	MCL1
CC	GO:0044464; cell part	GO:0097443; sorting endosome	2.793E-03	2.599E-01	PTPN1
CC	GO:0016020; membrane	GO:0016020; membrane	3.979E-03	3.103E-01	BACE1, DRD3, HTR2C, MCL1, OPRD1, PTPN1, PTPN2, VCP

Showing 1 to 10 of 12 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.075E-04	3.943E-03	OPRD1, HTR2C, DRD3
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	2.153E-03	2.045E-02	PTPN2, MCL1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	3.282E-02	8.733E-02	PTPN1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	6.128E-02	8.733E-02	MCL1
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4.325E-02	8.733E-02	HTR2C
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.930E-02	8.733E-02	HTR2C
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	5.659E-02	8.733E-02	DRD3
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	6.085E-02	8.733E-02	PTPN1
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	2.448E-02	8.733E-02	VCP
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	7.312E-02	8.733E-02	BACE1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	OPRD1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	OPRD1;
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	OPRD1;
I00-I99: Diseases of the circulatory system	Ischemic heart diseases	I20-I25	OPRD1;
K00-K95: Diseases of the digestive system	Diarrhea-predominant IBS	K58.0	OPRD1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	OPRD1;

Showing 1 to 10 of 16 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Eurybia divaricata

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities