Plant Name: Rubus alceifolius
Taxonomic Information:
Plant ID: NPO11222
Plant Latin Name: Rubus alceifolius
Taxonomy Genus: Rubus
Taxonomy Family: Rosaceae
Plant External Links:
NCBI TaxonomyDB:
124693
Plant-of-the-World-Online:
106335-3
Used in Medicines:
Unknown.
Geographical Distribution:
Myanmar; Indonesia; Mauritius; Vietnam; China; Laos; Thailand; Taiwan
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| PTPN1; | |
| AMY1A;AMY1B;AMY1C; HKDC1; HSD11B1; USP2; | |
| F10; ELANE; | |
| BACE1; | |
| MAPT; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| Enzyme_unclassified | AMY1A;AMY1B;AMY1C | Salivary alpha-amylase | P04745 | CHEMBL2478 |
| Enzyme_unclassified | HKDC1 | Putative hexokinase HKDC1 | Q2TB90 | CHEMBL1741200 |
| Enzyme_unclassified | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | P28845 | CHEMBL4235 |
| Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Serine protease | F10 | Coagulation factor X | P00742 | CHEMBL244 |
| Serine protease | ELANE | Leukocyte elastase | P08246 | CHEMBL248 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0051721; protein phosphatase 2A binding | 7.249E-05 | 7.530E-01 | MAPT, PTPN1 |
| BP | GO:0008152; metabolic process | GO:0033619; membrane protein proteolysis | 1.711E-02 | 1.000E+00 | BACE1 |
| MF | GO:0003824; catalytic activity | GO:0017171; serine hydrolase activity | 7.195E-03 | 1.000E+00 | ELANE, F10 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa04910 | Insulin signaling pathway | 1.672E-03 | 1.862E-02 | PTPN1, HKDC1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 2.429E-03 | 1.862E-02 | BACE1, MAPT |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00524 | Butirosin and neomycin biosynthesis | 2.248E-03 | 1.862E-02 | HKDC1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00010 | Glycolysis / Gluconeogenesis | 2.976E-02 | 5.219E-02 | HKDC1 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 2.976E-02 | 5.219E-02 | HKDC1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 2.580E-02 | 5.219E-02 | HSD11B1 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 3.282E-02 | 5.219E-02 | PTPN1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 3.238E-02 | 5.219E-02 | HSD11B1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04610 | Complement and coagulation cascades | 3.500E-02 | 5.219E-02 | F10 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 3.631E-02 | 5.219E-02 | HSD11B1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | HSD11B1; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Hemophilia | D66-D68 | F10; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Hematology | D50-D77 | F10; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | HSD11B1; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Attention deficit hyperactivity disorder | F90 | F10; |
| NA: NA | Haemophilia B | NA | F10; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypercholesterolemia | E78 | HSD11B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | HSD11B1; |
| I00-I99: Diseases of the circulatory system | Acute coronary syndrome | I74 | F10; |
| I00-I99: Diseases of the circulatory system | Angina pectoris | I20 | F10; |
| J00-J99: Diseases of the respiratory system | Influenza virus | J11.1 | HSD11B1; |
| I00-I99: Diseases of the circulatory system | Venous thromboembolism | I80-I82 | F10; |
| I00-I99: Diseases of the circulatory system | Venous thrombosis | I80-I82 | F10; |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | HSD11B1; |
| C00-D49: Neoplasms | Renal cancer | C64 | F10; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | HSD11B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | HSD11B1; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Blood coagulation disorders | D65-D68 | F10; |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | F10; |
| I00-I99: Diseases of the circulatory system | Prophylaxis of deep vein thrombosis | I80-I82, I80.2 | F10; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | HSD11B1; |
| NA: NA | Christmas disease | NA | F10; |
| I00-I99: Diseases of the circulatory system | Coagulation | I80-I82 | F10; |
| I00-I99: Diseases of the circulatory system | Deep venous clots | I80.2 | F10; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic syndrome x | E88.81 | HSD11B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Atrial fibrillation | E78, I48 | F10; |
| I00-I99: Diseases of the circulatory system | Thrombosis | I80-I82 | F10; |
| I00-I99: Diseases of the circulatory system | Thromboembolic disorders | I80-I82 | F10; |
| I00-I99: Diseases of the circulatory system | Thromboembolism | I80-I82 | F10; |
| I00-I99: Diseases of the circulatory system | Bleeding | I74, I80-I82 | F10; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | HSD11B1; |
| I00-I99: Diseases of the circulatory system | Deep vein thrombosis | I80-I82, I80.2 | F10; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
