CMAUP Plant Collective Molecular Activities

Plant Name: Trifolium hybridum

Taxonomic Information:

Plant ID: NPO11206
Plant Latin Name: Trifolium hybridum
Taxonomy Genus: Trifolium
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 74517
Plant-of-the-World-Online: 30240399-2

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Galactogogue

Geographical Distribution:

Turkey; Italy; Peru; France; Ireland; Argentina; Norway; Australia; Iran; Algeria; China; Chile; Belgium; Germany; Iraq; Kazakhstan; Spain; Ukraine; Netherlands; Denmark; Poland; Finland; United States; Morocco; Sweden; Belarus; Switzerland; New Zealand; Russia; Bulgaria; Romania; Albania; South Africa; Uruguay; India; United Kingdom; Austria; Colombia; Greece; Sri Lanka; Hungary; Tajikistan

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	FAAH; TERT; POLB;
Hydrolase	GAA;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Unclassified	FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	FAAH	Anandamide amidohydrolase	O00519	CHEMBL2243
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	8.514E-07	3.708E-03	PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	1.500E-06	4.453E-03	PPARA, PPARG
BP	GO:0051179; localization	GO:0015908; fatty acid transport	2.206E-06	4.453E-03	PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	2.250E-06	4.453E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	2.250E-06	4.453E-03	PPARA, PPARG
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	1.499E-06	4.453E-03	PPARA, PPARD, PPARG
BP	GO:0008152; metabolic process	GO:0006631; fatty acid metabolic process	3.604E-06	6.539E-03	FAAH, PPARA, PPARD, PPARG
BP	GO:0008152; metabolic process	GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter	8.240E-06	1.282E-02	PPARA, PPARD
MF	GO:0005488; binding	GO:0036041; long-chain fatty acid binding	8.240E-06	1.282E-02	PPARD, PPARG
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	1.126E-05	1.413E-02	PPARA, PPARD, PPARG
MF	GO:0005488; binding	GO:0001223; transcription coactivator binding	2.841E-05	1.933E-02	PPARA, TERT
MF	GO:0005488; binding	GO:0008134; transcription factor binding	5.469E-05	2.615E-02	PPARA, PPARD, PPARG, TERT
CC	GO:0043226; organelle	GO:0005654; nucleoplasm	3.052E-04	9.102E-02	FABP5, POLB, PPARA, PPARD, PPARG, TERT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	8.986E-09	2.157E-07	FABP5, PPARG, PPARA, PPARD
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	4.410E-03	5.251E-02	POLB, TERT
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.017E-02	5.251E-02	PPARG, PPARD
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	1.154E-02	5.251E-02	PPARG
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2.219E-02	6.773E-02	GAA
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	2.258E-02	6.773E-02	PPARD
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.194E-02	5.251E-02	GAA
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	1.313E-02	5.251E-02	POLB
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	4.816E-02	7.339E-02	GAA
09150 Organismal Systems	09158 Development	hsa04380	Osteoclast differentiation	5.161E-02	7.339E-02	PPARG

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases