Plant Name: Duranta erecta
Taxonomic Information:
Plant ID: NPO11186
Plant Latin Name: Duranta erecta
Taxonomy Genus: Duranta
Taxonomy Family: Verbenaceae
Plant External Links:
NCBI TaxonomyDB:
167917
Plant-of-the-World-Online:
330606-2
Used in Medicines:
Country/Region:
Pakistan; Indonesia; India; ThailandTraditional Medicine System:
Indian FolkGeographical Distribution:
Brazil; Madagascar; Bangladesh; Kenya; Sudan; Costa Rica; Cambodia; Bahamas; Ethiopia; Peru; Argentina; Bolivia; Venezuela; Malawi; Ecuador; Australia; Cuba; El Salvador; Zambia; Suriname; Guatemala; Zimbabwe; China; Thailand; Dominican Republic; Uganda; Pakistan; Indonesia; United States; Trinidad and Tobago; Gabon; Guyana; Honduras; Haiti; Jamaica; Angola; Chad; Mexico; Nicaragua; Uruguay; India; Mozambique; Colombia; Paraguay; French Guiana; Taiwan; Fiji
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| OPRD1; | |
| AMY1A;AMY1B;AMY1C; | |
| PTPRS; | |
| GRK6; KIT; | |
| RAB9A; NPC1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Enzyme_unclassified | AMY1A;AMY1B;AMY1C | Salivary alpha-amylase | P04745 | CHEMBL2478 |
| Peptide receptor (family A GPCR) | OPRD1 | Delta opioid receptor | P41143 | CHEMBL236 |
| Protein Kinase | GRK6 | G protein-coupled receptor kinase 6 | P43250 | CHEMBL6144 |
| Protein Kinase | KIT | Stem cell growth factor receptor | P10721 | CHEMBL1936 |
| Protein Phosphatase | PTPRS | Receptor-type tyrosine-protein phosphatase S | Q13332 | CHEMBL2396508 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 8.667E-06 | 1.648E-01 | CYP1A1, CYP1B1 |
| BP | GO:0022610; biological adhesion | GO:0090136; epithelial cell-cell adhesion | 2.308E-05 | 1.648E-01 | CYP1B1, KIT |
| BP | GO:0050896; response to stimulus | GO:0010035; response to inorganic substance | 3.700E-05 | 1.648E-01 | CYP1A1, CYP1B1, KIT, NPC1 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 4.034E-05 | 1.648E-01 | CYP1A1, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 4.858E-05 | 1.648E-01 | CYP1A1, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:1903409; reactive oxygen species biosynthetic process | 5.298E-05 | 1.648E-01 | CYP1A1, CYP1B1 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 4.858E-05 | 1.648E-01 | CYP1A1, CYP1B1 |
| BP | GO:0009987; cellular process | GO:0071310; cellular response to organic substance | 1.014E-04 | 2.453E-01 | CYP1A1, CYP1B1, KIT, NPC1, OPRD1 |
| CC | GO:0044464; cell part | GO:0005764; lysosome | 2.226E-04 | 3.171E-01 | KIT, NPC1, RAB9A |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 1.891E-04 | 3.171E-01 | CYP1A1, CYP1B1 |
| MF | GO:0003824; catalytic activity | GO:0070576; vitamin D 24-hydroxylase activity | 1.397E-03 | 4.226E-01 | CYP1A1 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 1.522E-03 | 4.359E-01 | CYP1A1, CYP1B1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 1.392E-04 | 2.545E-03 | CYP1A1, CYP1B1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 2.181E-04 | 2.545E-03 | CYP1A1, CYP1B1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 2.937E-04 | 2.545E-03 | CYP1A1, CYP1B1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 4.653E-04 | 3.024E-03 | CYP1A1, CYP1B1 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 5.867E-04 | 3.051E-03 | CYP1A1, CYP1B1 |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04144 | Endocytosis | 5.664E-03 | 2.454E-02 | KIT, GRK6 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 2.536E-02 | 8.596E-02 | KIT |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 2.976E-02 | 8.596E-02 | KIT |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 2.888E-02 | 8.596E-02 | CYP1A1 |
| 09160 Human Diseases | 09164 Substance dependence | hsa05032 | Morphine addiction | 4.022E-02 | 9.507E-02 | GRK6 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
