CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family A GPCR)	CNR2;
Enzyme_unclassified	TDP1; ALDH1A1; HPGD; SOAT1;
Transient receptor potential channel	TRPV1;
Oxidoreductase	MAOB;
Transcription Factor	TP53;
Unclassified	MAPT; MITF; LMNA; NPC1; RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP3A4;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	SOAT1	Acyl coenzyme A:cholesterol acyltransferase 1	P35610	CHEMBL2782
Oxidoreductase	MAOB	Monoamine oxidase B	P27338	CHEMBL2039
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096

Showing 1 to 10 of 16 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0034605; cellular response to heat	6.478E-06	2.934E-02	MAPT, TP53, TRPV1
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	9.292E-06	2.996E-02	CYP1A2, HPGD, MAOB, NPC1, TRPV1, TSHR
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	9.631E-06	2.996E-02	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	1.348E-05	3.008E-02	CYP1A2, CYP3A4
BP	GO:0050896; response to stimulus	GO:0033993; response to lipid	1.551E-05	3.008E-02	CNR2, CYP1A2, HPGD, MAOB, NPC1, TP53
MF	GO:0005488; binding	GO:0048037; cofactor binding	1.534E-06	2.799E-02	ALDH1A1, CYP1A2, CYP3A4, HPGD, MAOB, SOAT1
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	3.856E-06	2.799E-02	CYP1A2, CYP3A4
MF	GO:0005488; binding	GO:0005496; steroid binding	4.576E-05	4.794E-02	CYP3A4, NPC1, SOAT1

Showing 1 to 8 of 8 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.780E-05	7.566E-04	CYP1A2, ALDH1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.131E-05	7.566E-04	MAOB, CYP1A2, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	4.598E-04	8.161E-03	MAOB, CYP1A2
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.406E-04	5.693E-03	CYP1A2, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9.663E-04	1.354E-02	CYP1A2, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.526E-03	1.354E-02	CYP1A2, CYP3A4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	3.994E-03	2.836E-02	CYP1A2
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.288E-03	1.354E-02	CNR2, TRPV1, TSHR
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	1.444E-03	1.354E-02	MITF, TP53
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.920E-03	1.514E-02	CYP1A2, CYP3A4

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	MAOB;
A00-B99: Certain infectious and parasitic diseases	Postherpetic neuralgia	B02.2, G44.847, G53.0	TRPV1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	CNR2;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	TRPV1;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Immune disorder	D80-D89	CNR2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	TRPV1;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	MAOB;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAOB;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOB;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Idiopathic parkinson's disease	F02.3, G20	MAOB;

Showing 1 to 10 of 35 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Dichotomanthes tristaniicarpa

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities