CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Unclassified	NPC1; LMNA; RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Showing 1 to 3 of 3 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032501; multicellular organismal process	GO:0055015; ventricular cardiac muscle cell development	1.552E-03	1.000E+00	LMNA
BP	GO:0009987; cellular process	GO:0071404; cellular response to low-density lipoprotein particle stimulus	2.173E-03	1.000E+00	NPC1
BP	Unclassified;	GO:2000188; regulation of cholesterol homeostasis	2.173E-03	1.000E+00	NPC1
BP	GO:0009987; cellular process	GO:0090201; negative regulation of release of cytochrome c from mitochondria	2.638E-03	1.000E+00	LMNA
BP	GO:0051179; localization	GO:0033344; cholesterol efflux	3.723E-03	1.000E+00	NPC1
BP	GO:0007610; behavior	GO:0007628; adult walking behavior	4.188E-03	1.000E+00	NPC1
BP	GO:0009987; cellular process	GO:0007077; mitotic nuclear envelope disassembly	6.819E-03	1.000E+00	LMNA
BP	GO:0009987; cellular process	GO:0060548; negative regulation of cell death	7.070E-03	1.000E+00	LMNA, NPC1
BP	GO:0051179; localization	GO:0032880; regulation of protein localization	8.236E-03	1.000E+00	LMNA, RAB9A
BP	GO:0050896; response to stimulus	GO:0046686; response to cadmium ion	8.673E-03	1.000E+00	NPC1

Showing 1 to 10 of 19 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.085E-02	2.085E-02	LMNA
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	1.834E-02	2.085E-02	NPC1
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	1.106E-02	2.085E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	1.240E-02	2.085E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	1.344E-02	2.085E-02	LMNA
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	2.026E-02	2.085E-02	RAB9A

Showing 1 to 6 of 6 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Aglaia tomentosa

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities