CMAUP Plant Collective Molecular Activities

Plant Name: Allium rosenorum

Taxonomic Information:

Plant ID: NPO11061
Plant Latin Name: Allium rosenorum
Taxonomy Genus: Allium
Taxonomy Family: Amaryllidaceae

Plant External Links:

NCBI TaxonomyDB: 543701
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Tajikistan

Traditional Medicine System:

Geographical Distribution:

Tajikistan

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	ALPI; ALPL; TDP1; HPGD; AKR1B1; HSD17B10; ALDH1A1; CD38; POLB;
Hydrolase	GAA;
Lyase	CA2; CA1; CA12; CA9; CA7; CA5A; CA3; CA14; CA5B; CA4; CA6;
Lysine demethylase	KDM4E;
Transcription Factor	NFKB1;
Transferase	FUT7;
Unclassified	LMNA; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALPI	Intestinal alkaline phosphatase	P09923	CHEMBL5573
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	CD38	Lymphocyte differentiation antigen CD38	P28907	CHEMBL4660
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.972E-09	5.884E-06	ALPI, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.014E-30	6.563E-26	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	5.222E-06	7.581E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.659E-23	1.806E-19	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	6.660E-22	2.900E-18	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0050896; response to stimulus	GO:0009636; response to toxic substance	1.266E-05	1.451E-02	AKR1B1, ALPL, CA3, HPGD, NFKB1, POLB
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	1.965E-05	2.139E-02	AKR1B1, ALPL, CA2, CA9, CD38, HPGD, NFKB1
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.605E-05	2.578E-02	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0004035; alkaline phosphatase activity	2.605E-05	2.578E-02	ALPI, ALPL

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.861E-29	1.489E-27	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.212E-04	3.906E-03	FUT7, GAA, ALDH1A1, CD38, AKR1B1, ALPL, ALPI, HSD17B10
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4.043E-04	8.086E-03	CA2, CA4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	6.913E-04	1.106E-02	GAA, AKR1B1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1.465E-04	3.906E-03	ALPL, ALPI
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	6.875E-03	9.166E-02	CA2, CD38
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.417E-02	1.619E-01	LMNA, NFKB1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.997E-02	1.732E-01	MAPT, HSD17B10
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	2.272E-02	1.732E-01	HPGD, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	4.305E-02	1.732E-01	MAPT, NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases