CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1;
Transient receptor potential channel	TRPA1;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Metallo protease	MMP9;
Toll-like and Il-1 receptors	TLR2;
Unclassified	FABP3; LMNA; FABP2; FABP4; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Showing 1 to 10 of 11 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	7.155E-10	5.194E-06	FABP2, FABP3, FABP4, FABP5
BP	GO:0051179; localization	GO:0015908; fatty acid transport	6.452E-06	8.781E-03	FABP3, PPARA, PPARD
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	9.679E-06	1.171E-02	LMNA, PPARA, PPARD, TLR2
BP	GO:0008152; metabolic process	GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter	1.617E-05	1.601E-02	PPARA, PPARD
MF	GO:0005488; binding	GO:0036041; long-chain fatty acid binding	1.617E-05	1.601E-02	FABP3, PPARD

Showing 1 to 5 of 5 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	6.152E-13	2.399E-11	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	3.784E-02	9.105E-02	PPARA
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5.261E-02	9.105E-02	TRPA1
09150 Organismal Systems	09151 Immune system	hsa04670	Leukocyte transendothelial migration	6.303E-02	9.105E-02	MMP9
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	2.788E-03	5.436E-02	MMP9, TLR2
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	5.309E-03	6.901E-02	MMP9, TLR2
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	2.984E-02	9.105E-02	TLR2
09160 Human Diseases	09162 Immune diseases	hsa05321	Inflammatory bowel disease (IBD)	3.518E-02	9.105E-02	TLR2
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	3.997E-02	9.105E-02	LMNA
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	6.303E-02	9.105E-02	TLR2

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Paederia scandens

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities