CMAUP Plant Collective Molecular Activities

Plant Name: Sargentodoxa cuneata

Taxonomic Information:

Plant ID: NPO10994
Plant Latin Name: Sargentodoxa cuneata
Taxonomy Genus: Sargentodoxa
Taxonomy Family: Lardizabalaceae

Plant External Links:

NCBI TaxonomyDB: 50506
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Anthelmintic; Antibacterial; Antirheumatic; Carminative; Diuretic; Stimulant; Tonic

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	GAA;
Enzyme_unclassified	ALPL; TDP1; AKR1B10; AKR1B1; HSD17B10; ALDH1A1; APEX1;
Protein Kinase	PRKCA;
Lyase	CA2; CA1; CA12; CA9; CA5B; CA5A; CA3; CA14; CA7; CA4; CA6;
Transcription Factor	NFKB1;
Unclassified	HTT; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	5.842E-10	1.272E-06	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, PRKCA
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.278E-31	1.149E-26	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.066E-06	5.902E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.917E-24	3.176E-20	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.440E-22	6.270E-19	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors	1.892E-05	2.168E-02	AKR1B1, AKR1B10, ALDH1A1
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.028E-05	2.209E-02	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0001758; retinal dehydrogenase activity	2.838E-05	2.943E-02	AKR1B10, ALDH1A1
BP	GO:0008152; metabolic process	GO:0044597; daunorubicin metabolic process	3.781E-05	3.293E-02	AKR1B1, AKR1B10
BP	GO:0008152; metabolic process	GO:0044598; doxorubicin metabolic process	3.781E-05	3.293E-02	AKR1B1, AKR1B10

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.260E-30	3.814E-28	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	5.285E-06	3.092E-04	AKR1B10, GAA, AKR1B1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3.154E-04	1.230E-02	CA2, CA4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	7.783E-04	1.821E-02	AKR1B10, AKR1B1
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.261E-03	3.780E-02	AKR1B10, GAA, ALDH1A1, AKR1B1, ALPL, HSD17B10
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6.144E-04	1.797E-02	AKR1B10, AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	2.080E-03	3.780E-02	AKR1B10, AKR1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	3.004E-03	4.224E-02	PRKCA, MAPT, NFKB1
09150 Organismal Systems	09154 Digestive system	hsa04971	Gastric acid secretion	3.249E-03	4.224E-02	CA2, PRKCA
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	5.402E-03	5.573E-02	CA2, PRKCA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; CA9;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases