CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	BCR;
Lyase	CA2; CA5A; CA6; CA12; CA1; CA9; CA5B;
Enzyme_unclassified	GFER; NQO2; HPGD;
Oxidoreductase	PTGS1; PTGS2;
Lysine demethylase	KDM4E;
Unclassified	NPC1; PAX8; RAB9A; HTT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP3A4;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	NQO2	Quinone reductase 2	P16083	CHEMBL3959
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.189E-14	1.589E-10	CA1, CA12, CA2, CA5A, CA5B, CA6, CA9
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.237E-07	2.072E-04	CYP1A1, CYP1B1, CYP3A4, NQO2, PTGS1
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	1.729E-07	2.689E-04	CYP1A1, CYP1B1, CYP3A4, GFER, HPGD, KDM4E, NQO2, PTGS1, PTGS2
BP	GO:0050896; response to stimulus	GO:0033993; response to lipid	7.279E-06	4.803E-03	BCR, CA2, CA9, CYP1A1, HPGD, NPC1, PTGS2
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	7.616E-06	4.877E-03	CA2, CA9, CYP1A1, CYP1B1, HPGD, NPC1, PTGS2
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	1.684E-05	8.732E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.792E-15	5.218E-11	CA1, CA12, CA2, CA5A, CA5B, CA6, CA9
MF	GO:0005488; binding	GO:0020037; heme binding	2.208E-07	3.005E-04	CYP1A1, CYP1B1, CYP3A4, PTGS1, PTGS2
MF	GO:0003824; catalytic activity	GO:0004666; prostaglandin-endoperoxide synthase activity	1.126E-06	1.025E-03	PTGS1, PTGS2
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.188E-06	1.035E-03	CA1, CA12, CA2, CA5A, CA5B, CA6, CA9, NQO2

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.859E-18	3.189E-16	CA12, CA1, CA5B, CA2, CA5A, CA6, CA9
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.966E-05	2.670E-04	CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.919E-05	4.261E-04	CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	7.996E-04	4.797E-03	CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.912E-03	8.395E-03	PTGS2, PTGS1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.099E-03	8.395E-03	CYP1A1, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.894E-05	2.273E-04	CYP1A1, CYP1B1, PTGS2
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.563E-03	8.037E-03	PTGS2, PTGS1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.498E-03	8.993E-03	CA2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.489E-06	2.681E-05	CYP1A1, CYP1B1, CYP3A4, PTGS2

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	PTGS2;
C00-D49: Neoplasms	Pancreatic cancer	C25	PTGS2;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	PTGS1;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	PTGS2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS1; PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	PTGS1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	PTGS1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	PTGS2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Pterocarpus santalinus

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities