CMAUP Plant Collective Molecular Activities

Plant Name: Eucalyptus camaldulensis

Taxonomic Information:

Plant ID: NPO10849
Plant Latin Name: Eucalyptus camaldulensis
Taxonomy Genus: Eucalyptus
Taxonomy Family: Myrtaceae

Plant External Links:

NCBI TaxonomyDB: 34316
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

India; Australia; Italy; Burkina Faso

Traditional Medicine System:

Indian Folk

Medicinal Functions:

Antiseptic; Astringent

Geographical Distribution:

Italy; Australia; India; Burkina Faso

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	ALPL; ALOX12; ALOX15; HSD17B10; IDH1; USP2;
Hydrolase	GAA;
Oxidoreductase	PTGS2; PTGS1; MAOA;
Transcription Factor	NFKB1; RELA;
Unclassified	MAPT; LMNA; XBP1;
Transferase	FASN;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	IDH1	Isocitrate dehydrogenase [NADP] cytoplasmic	O75874	CHEMBL2007625
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transcription Factor	RELA	Nuclear factor NF-kappa-B p65 subunit	Q04206	CHEMBL5533
Transferase	FASN	Fatty acid synthase	P49327	CHEMBL4158
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	XBP1	X-box-binding protein 1	P17861	CHEMBL1741176

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	3.536E-12	7.700E-08	ALOX12, ALOX15, CYP19A1, CYP2C19, CYP2C9, FASN, GAA, HSD17B10, IDH1, MAOA, PTGS1, PTGS2
MF	GO:0005488; binding	GO:0020037; heme binding	1.275E-07	1.322E-04	CYP19A1, CYP2C19, CYP2C9, PTGS1, PTGS2
MF	GO:0005488; binding	GO:0005506; iron ion binding	3.878E-07	3.127E-04	ALOX12, ALOX15, CYP19A1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	4.482E-07	3.486E-04	ALOX12, ALOX15, PTGS2
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	9.167E-07	5.871E-04	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0004666; prostaglandin-endoperoxide synthase activity	9.167E-07	5.871E-04	PTGS1, PTGS2
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	9.167E-07	5.871E-04	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0050473; arachidonate 15-lipoxygenase activity	2.748E-06	1.460E-03	ALOX15, PTGS2
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	2.748E-06	1.460E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	2.748E-06	1.460E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	4.736E-06	2.398E-03	CYP19A1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	9.151E-06	4.151E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:2000630; positive regulation of miRNA metabolic process	9.151E-06	4.151E-03	NFKB1, RELA
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.115E-05	4.957E-03	CYP19A1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.372E-05	5.857E-03	CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0046890; regulation of lipid biosynthetic process	1.888E-05	7.463E-03	FASN, IDH1, NFKB1, PTGS2
BP	GO:0032501; multicellular organismal process	GO:0045075; regulation of interleukin-12 biosynthetic process	1.919E-05	7.463E-03	NFKB1, RELA
CC	GO:0032991; macromolecular complex	GO:0033256; I-kappaB/NF-kappaB complex	1.919E-05	7.463E-03	NFKB1, RELA
BP	GO:0050896; response to stimulus	GO:0009750; response to fructose	2.558E-05	9.440E-03	PTGS2, XBP1
BP	GO:0009987; cellular process	GO:0071316; cellular response to nicotine	2.558E-05	9.440E-03	NFKB1, RELA
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	1.836E-04	3.702E-02	CYP19A1, CYP2C19, CYP2C9, PTGS1, PTGS2, XBP1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.561E-12	3.336E-10	MAOA, GAA, IDH1, ALOX15, ALOX12, PTGS2, CYP2C19, CYP19A1, HSD17B10, PTGS1, CYP2C9, FASN, ALPL
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.820E-11	5.946E-10	CYP2C9, ALOX15, ALOX12, CYP2C19, PTGS2, PTGS1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	6.808E-12	3.336E-10	CYP2C9, MAOA, ALOX15, ALOX12, CYP2C19, PTGS2, PTGS1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.615E-06	6.406E-05	CYP2C9, ALOX15, CYP2C19
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	1.303E-05	2.553E-04	MAOA, RELA, NFKB1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3.660E-05	5.979E-04	CYP2C9, MAOA, CYP2C19
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	4.335E-05	6.069E-04	PTGS2, RELA, NFKB1
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	7.077E-05	7.706E-04	PTGS2, RELA, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	1.471E-04	1.311E-03	PTGS2, RELA, NFKB1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	6.139E-05	7.520E-04	CYP2C9, CYP2C19, PTGS2
09130 Environmental Information Processing	09132 Signal transduction	hsa04064	NF-kappa B signaling pathway	8.936E-05	8.757E-04	PTGS2, RELA, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.996E-04	2.447E-03	LMNA, RELA, NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04932	Non-alcoholic fatty liver disease (NAFLD)	3.741E-04	2.820E-03	XBP1, RELA, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.019E-03	7.051E-03	PTGS2, CYP19A1
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	1.706E-03	7.051E-03	MAPT, RELA, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.277E-03	7.051E-03	PTGS2, PTGS1
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.232E-03	7.051E-03	RELA, NFKB1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.323E-03	7.051E-03	RELA, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	1.765E-03	7.051E-03	XBP1, RELA, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	1.323E-03	7.051E-03	RELA, NFKB1
09160 Human Diseases	09162 Immune diseases	hsa05321	Inflammatory bowel disease (IBD)	1.716E-03	7.051E-03	RELA, NFKB1
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.769E-03	7.051E-03	RELA, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04623	Cytosolic DNA-sensing pathway	1.664E-03	7.051E-03	RELA, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1.876E-03	7.051E-03	RELA, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	2.101E-03	7.051E-03	RELA, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05131	Shigellosis	1.716E-03	7.051E-03	RELA, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	2.159E-03	7.051E-03	RELA, NFKB1
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	2.159E-03	7.051E-03	RELA, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	1.987E-03	7.051E-03	RELA, NFKB1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	3.187E-03	9.466E-03	RELA, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04622	RIG-I-like receptor signaling pathway	1.987E-03	7.051E-03	RELA, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	2.277E-03	7.197E-03	RELA, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05132	Salmonella infection	2.980E-03	9.126E-03	RELA, NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	PTGS1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	PTGS1;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	PTGS1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	PTGS1;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	PTGS1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PTGS1;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	PTGS1;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	PTGS1;
NA: NA	Miosis during ocular surgery	NA	PTGS1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Postoperative inflammation	T81	PTGS1;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
NA: NA	Rheumatold arthritis	NA	PTGS1;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS1;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTGS1;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	PTGS1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases