CMAUP Plant Collective Molecular Activities

Plant Name: Protea compacta

Taxonomic Information:

Plant ID: NPO10834
Plant Latin Name: Protea compacta
Taxonomy Genus: Protea
Taxonomy Family: Proteaceae

Plant External Links:

NCBI TaxonomyDB: 273580
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADRA2C; ADRA2A; HRH3;
Peptide receptor (family A GPCR)	TSHR;
Nuclear hormone receptor subfamily 3 group C	NR3C1;
Transcription Factor	NFKB1; HIF1A;
Plant homeodomain	KMT2A;
Unclassified	SERPINA6; MAPT;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 3 group C	NR3C1	Glucocorticoid receptor	P04150	CHEMBL2034
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Plant homeodomain	KMT2A	Histone-lysine N-methyltransferase MLL	Q03164	CHEMBL1293299
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867
Small molecule receptor (family A GPCR)	HRH3	Histamine H3 receptor	Q9Y5N1	CHEMBL264
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	SERPINA6	Corticosteroid binding globulin	P08185	CHEMBL2421
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	8.994E-07	5.776E-03	HIF1A, MAPT, NR3C1
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	1.061E-06	5.776E-03	ADRA2A, ADRA2C
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	2.121E-06	7.199E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	2.121E-06	7.199E-03	ADRA2A, ADRA2C
BP	GO:0065007; biological regulation	GO:0045761; regulation of adenylate cyclase activity	2.561E-06	7.199E-03	ADRA2A, HRH3, TSHR
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	8.466E-06	1.121E-02	ADRA2A, ADRA2C, HIF1A, NFKB1, SERPINA6
BP	GO:0009987; cellular process	GO:0010700; negative regulation of norepinephrine secretion	9.886E-06	1.121E-02	ADRA2A, ADRA2C
MF	GO:0005488; binding	GO:0051379; epinephrine binding	9.886E-06	1.121E-02	ADRA2A, ADRA2C
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	2.327E-05	1.635E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	2.749E-05	1.710E-02	SMN1, SMN2
MF	GO:0005488; binding	GO:0031690; adrenergic receptor binding	5.383E-05	2.494E-02	ADRA2A, ADRA2C
CC	GO:0044464; cell part	GO:0034719; SMN-Sm protein complex	5.383E-05	2.494E-02	SMN1, SMN2
MF	GO:0005488; binding	GO:0042803; protein homodimerization activity	7.254E-05	2.976E-02	ADRA2A, ADRA2C, KMT2A, MAPT, NFKB1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3.596E-07	2.373E-05	HRH3, ADRA2C, NR3C1, ADRA2A, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.676E-03	5.531E-02	HIF1A, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	4.330E-03	6.614E-02	ADRA2C, ADRA2A
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	4.586E-03	6.614E-02	SMN2, SMN1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	6.089E-03	6.697E-02	NFKB1, TSHR
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	5.010E-03	6.614E-02	KMT2A, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	9.824E-03	9.262E-02	MAPT, NFKB1
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	3.890E-02	9.388E-02	HIF1A
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	3.948E-02	9.388E-02	HIF1A
09150 Organismal Systems	09151 Immune system	hsa04623	Cytosolic DNA-sensing pathway	3.774E-02	9.388E-02	NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
NA: NA	Corticosteroid-responsive inflammation	NA	NR3C1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	NR3C1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep disorders	F51, G47	HRH3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	NR3C1; HRH3;
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C; NR3C1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A;
S00-T88: Injury, poisoning and certain other consequences of external causes	Skin allergies	T78.4	NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Xerophthalmia	E50.6-E50.7	NR3C1;
G00-G99: Diseases of the nervous system G00-G99	Ataxia telangiectasia	G11.3	NR3C1;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADRA2C; NR3C1; SERPINA6;
L00-L99: Diseases of the skin and subcutaneous tissue	Eczema	L20-L30	NR3C1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A; HRH3;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	NR3C1;
G00-G99: Diseases of the nervous system G00-G99	Narcolepsy	G47.4	HRH3;
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HRH3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Excessive daytime sleepiness	F51.1, G47.1	HRH3;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; NR3C1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C; NR3C1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	HRH3;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	NR3C1;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	HRH3;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADRA2C;
E00-E89: Endocrine, nutritional and metabolic diseases	Cushing's disease	E24.0	NR3C1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ADRA2C;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HRH3;
NA: NA	Obstructive airway diseases	NA	SERPINA6;
G00-G99: Diseases of the nervous system G00-G99	Duchenne muscular dystrophy	G71.0	NR3C1;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; HIF1A; NR3C1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADRA2C;
H00-H59: Diseases of the eye and adnexa	Diabetic retinopathy	H36, E10.3, E11.3, E13.3	SERPINA6;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic macular edema	E08-E13, E08.3, E09.3, E10.3, E11.3, E13.3, H35.8, R60.9	SERPINA6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	ADRA2C;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	HRH3;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HRH3;
H60-H95: Diseases of the ear and mastoid process	Otitis externa	H60	NR3C1;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	NR3C1;
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C;
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	HRH3;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	NR3C1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	NR3C1; SERPINA6;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	NR3C1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C;
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ADRA2C; HRH3;
NA: NA	Non-infectious rhinitis	NA	NR3C1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ADRA2C; HRH3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Musculoskeletal pain	R52, G89	HRH3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADRA2A; ADRA2C; HRH3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2C; HRH3;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	HRH3;
E00-E89: Endocrine, nutritional and metabolic diseases	Obese insulin-resistant disorders	E11	HRH3;
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	NR3C1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	NR3C1;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A;
S00-T88: Injury, poisoning and certain other consequences of external causes	Spinal cord injury	S14, S24, S34	NR3C1;
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	HRH3;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C; HRH3;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADRA2C; NR3C1; HRH3;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases