CMAUP Plant Collective Molecular Activities

Plant Name: Bletilla striata

Taxonomic Information:

Plant ID: NPO10780
Plant Latin Name: Bletilla striata
Taxonomy Genus: Bletilla
Taxonomy Family: Orchidaceae

Plant External Links:

NCBI TaxonomyDB: 78707
Plant-of-the-World-Online: 617803-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Antibacterial; Antiinflammatory; Antiphlogistic; Demulcent; Pectoral; Skin; Styptic; Vulnerary

Geographical Distribution:

Japan; China; Myanmar; South Africa

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family A GPCR)	HCAR2;
Enzyme_unclassified	TDP1;
Hydrolase	GAA;
Lyase	CA2; CA1; CA7; CA5A; CA4; CA6; CA12; CA9; CA5B; CA14;
Serine protease	ELANE;
Unclassified	MAPT;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Serine protease	ELANE	Leukocyte elastase	P08246	CHEMBL248
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.457E-10	5.945E-07	CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, L3MBTL1
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.933E-29	6.387E-25	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	2.186E-06	3.087E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.400E-23	2.613E-19	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.200E-21	1.198E-17	CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.091E-05	1.251E-02	CA1, CA2
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.796E-05	1.956E-02	CA2, CA4, CA9, TSHR
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	3.267E-05	3.388E-02	CA2, CA7

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.340E-28	2.547E-27	CA12, CA1, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.703E-04	1.617E-03	CA2, CA4
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.214E-02	7.691E-02	HCAR2, TSHR
09150 Organismal Systems	09155 Excretory system	hsa04966	Collecting duct acid secretion	2.271E-02	9.578E-02	CA2
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	2.521E-02	9.578E-02	GAA
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	4.412E-02	1.055E-01	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4.657E-02	1.055E-01	TSHR
09150 Organismal Systems	09154 Digestive system	hsa04971	Gastric acid secretion	6.110E-02	1.055E-01	CA2
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	5.869E-02	1.055E-01	TSHR
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	5.869E-02	1.055E-01	CA2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases