Plant Name: Callitris drummondii
Taxonomic Information:
Plant ID: NPO10756
Plant Latin Name: Callitris drummondii
Taxonomy Genus: Callitris
Taxonomy Family: Cupressaceae
Plant External Links:
NCBI TaxonomyDB:
214233
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ALPI; AKR1B1; POLB; | |
| GAA; | |
| CA2; CA7; CA4; CA12; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | ALPI | Intestinal alkaline phosphatase | P09923 | CHEMBL5573 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 2.959E-11 | 6.444E-07 | CA12, CA2, CA4, CA7 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.272E-09 | 9.229E-06 | CA12, CA2, CA4, CA7 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 2.925E-09 | 1.593E-05 | CA12, CA2, CA4, CA7 |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 5.788E-07 | 1.801E-03 | CA2, CA7 |
| BP | GO:0065007; biological regulation | GO:0042592; homeostatic process | 8.557E-06 | 1.887E-02 | AKR1B1, CA12, CA2, CA7, GAA, POLB |
| BP | GO:0051179; localization | GO:2001225; regulation of chloride transport | 8.667E-06 | 1.887E-02 | CA2, CA7 |
| BP | GO:0023052; signaling | GO:0032230; positive regulation of synaptic transmission, GABAergic | 1.501E-05 | 2.724E-02 | CA2, CA7 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 1.427E-05 | 2.724E-02 | ALPI, CA12, CA2, CA4, CA7 |
| MF | GO:0003824; catalytic activity | GO:0004574; oligo-1,6-glucosidase activity | 9.317E-04 | 4.410E-01 | GAA |
| MF | GO:0003824; catalytic activity | GO:0032450; maltose alpha-glucosidase activity | 1.397E-03 | 5.130E-01 | GAA |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 3.176E-03 | 8.248E-01 | CA2, CA4 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 4.488E-11 | 9.425E-10 | CA12, CA2, CA4, CA7 |
| 09150 Organismal Systems | 09155 Excretory system | hsa04964 | Proximal tubule bicarbonate reclamation | 4.532E-05 | 4.759E-04 | CA2, CA4 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 7.779E-05 | 5.446E-04 | GAA, AKR1B1 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 1.502E-02 | 3.754E-02 | GAA, AKR1B1, ALPI |
| 09150 Organismal Systems | 09155 Excretory system | hsa04966 | Collecting duct acid secretion | 1.209E-02 | 3.754E-02 | CA2 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 1.609E-02 | 3.754E-02 | AKR1B1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 1.431E-02 | 3.754E-02 | AKR1B1 |
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 1.476E-02 | 3.754E-02 | POLB |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00790 | Folate biosynthesis | 6.284E-03 | 3.299E-02 | ALPI |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 3.151E-02 | 4.923E-02 | CA2 |
Human Diseases Associated with the Target Proteins of the Plant
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
