CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	EGFR;
Lyase	CA1; CA5B; CA5A; CA6; CA12; CA9;
Nuclear hormone receptor subfamily 1 group A	THRB;
Lysine demethylase	KDM4E;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP3A4;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Nuclear hormone receptor subfamily 1 group A	THRB	Thyroid hormone receptor beta-1	P10828	CHEMBL1947

Showing 1 to 10 of 11 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.240E-14	1.350E-10	CA1, CA12, CA5A, CA5B, CA6, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.486E-14	3.256E-10	CA1, CA12, CA5A, CA5B, CA6, CA9
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	8.842E-07	1.605E-03	CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	4.417E-06	5.658E-03	CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.940E-05	2.223E-02	CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0008270; zinc ion binding	6.492E-08	1.571E-04	CA1, CA12, CA5A, CA5B, CA6, CA9, THRB
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.201E-17	6.971E-13	CA1, CA12, CA5A, CA5B, CA6, CA9

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.422E-17	2.954E-15	CA12, CA1, CA5B, CA5A, CA6, CA9
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.323E-04	1.085E-02	CYP2D6, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.075E-04	1.085E-02	CYP2D6, CYP3A4
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	5.523E-02	9.771E-02	EGFR
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	3.997E-02	9.771E-02	EGFR
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	4.736E-02	9.771E-02	EGFR
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	4.894E-02	9.771E-02	EGFR
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	5.314E-02	9.771E-02	EGFR
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	5.418E-02	9.771E-02	EGFR
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	4.420E-02	9.771E-02	CYP3A4

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;

Showing 1 to 7 of 7 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Marshallia graminifolia

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities