Plant Name: Acnistus arborescens
Taxonomic Information:
Plant ID: NPO10618
Plant Latin Name: Acnistus arborescens
Taxonomy Genus: Acnistus
Taxonomy Family: Solanaceae
Plant External Links:
NCBI TaxonomyDB:
362341
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Unclassified | RAD52 | DNA repair protein RAD52 homolog | P43351 | CHEMBL2362978 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0032501; multicellular organismal process | GO:0055015; ventricular cardiac muscle cell development | 1.035E-03 | 1.000E+00 | LMNA |
| BP | GO:0009987; cellular process | GO:0090201; negative regulation of release of cytochrome c from mitochondria | 1.759E-03 | 1.000E+00 | LMNA |
| BP | GO:0009987; cellular process | GO:0007077; mitotic nuclear envelope disassembly | 4.551E-03 | 1.000E+00 | LMNA |
| BP | GO:0009987; cellular process | GO:2001237; negative regulation of extrinsic apoptotic signaling pathway | 1.064E-02 | 1.000E+00 | LMNA |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 1.074E-02 | 1.000E+00 | LMNA |
| BP | GO:0008152; metabolic process | GO:0006310; DNA recombination | 1.958E-02 | 1.000E+00 | RAD52 |
| BP | GO:0009987; cellular process | GO:0034599; cellular response to oxidative stress | 1.999E-02 | 1.000E+00 | RAD52 |
| BP | GO:0051179; localization | GO:1900180; regulation of protein localization to nucleus | 2.275E-02 | 1.000E+00 | LMNA |
| BP | GO:0009987; cellular process | GO:0051260; protein homooligomerization | 3.092E-02 | 1.000E+00 | RAD52 |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 2.442E-02 | 1.000E+00 | LMNA, RAD52 |
| CC | GO:0043226; organelle | GO:0016607; nuclear speck | 3.784E-02 | 1.000E+00 | LMNA |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03440 | Homologous recombination | 2.898E-03 | 1.122E-02 | RAD52 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 7.386E-03 | 1.122E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 8.283E-03 | 1.122E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 8.980E-03 | 1.122E-02 | LMNA |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 1.395E-02 | 1.395E-02 | LMNA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
