CMAUP Plant Collective Molecular Activities

Plant Name: Arctium lappa

Taxonomic Information:

Plant ID: NPO10449
Plant Latin Name: Arctium lappa
Taxonomy Genus: Arctium
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 4217
Plant-of-the-World-Online: 178385-1

Used in Medicines:

Country/Region:

India; South Korea; Finland; Italy; China

Traditional Medicine System:

Indian Folk; TCM; Homeopathy; Kampo

Medicinal Functions:

Alterative; Antibacterial; Antifungal; Antiphlogistic; Antipsoriatic; Aperient; Blood purifier; Carminative; Cholagogue; Depurative; Diaphoretic; Diuretic; Hypoglycaemic; Stomachic

Geographical Distribution:

Canada; Afghanistan; Italy; Turkmenistan; Nepal; Cambodia; France; Netherlands; Ireland; Laos; Norway; Uzbekistan; Australia; Iceland; China; Belgium; Germany; Kazakhstan; Taiwan; Spain; Ukraine; Georgia; Denmark; Poland; Finland; Turkey; United States; Sweden; Belarus; Japan; Switzerland; New Zealand; Russia; Bulgaria; Romania; Greenland; Portugal; Myanmar; South Africa; Tajikistan; India; United Kingdom; Austria; Vietnam; Greece; Hungary; South Korea; Cyprus

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Enzyme_unclassified	RECQL; ALOX12; HSD17B10; NOX4; POLB;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; MAP2K1; KDR; IGF1R; AURKB;
Lyase	CA12; CA7; CA4;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Metallo protease	MMP12; MMP9; MMP1; MMP2;
Transcription Factor	HIF1A; NFKB1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP3A4; CYP1B1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	CHEMBL3587
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	4.405E-08	5.329E-05	ALOX12, CDK1, FLT3, HIF1A, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, TSHR
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	2.030E-07	1.637E-04	HIF1A, MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	3.603E-07	2.615E-04	AXL, FLT3, IGF1R, KDR, MAP2K1, MET
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	5.782E-07	3.703E-04	HIF1A, MMP1, MMP12, MMP2, MMP9
MF	GO:0005488; binding	GO:0019825; oxygen binding	6.737E-07	4.192E-04	CYP1B1, CYP2C19, CYP3A4, NOX4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.519E-06	7.692E-04	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.556E-06	1.184E-03	CA12, CA4, CA7, MMP1, MMP12, MMP2, MMP9, NR1H4, RORC
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	2.996E-06	1.359E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0010557; positive regulation of macromolecule biosynthetic process	3.208E-06	1.420E-03	AURKB, CDK1, HIF1A, IGF1R, KDR, MAP2K1, MET, MMP12, NFKB1, NOX4, NR1H4, RORC
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	6.550E-06	2.231E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0031328; positive regulation of cellular biosynthetic process	6.558E-06	2.231E-03	AURKB, CDK1, HIF1A, IGF1R, MAP2K1, MET, MMP12, NFKB1, NOX4, NR1H4, RORC, TSHR
BP	GO:0008152; metabolic process	GO:0006508; proteolysis	1.130E-05	3.195E-03	AURKB, CDK1, HIF1A, MAP2K1, MMP1, MMP12, MMP2, MMP9, NFKB1, POLB
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	1.185E-05	3.309E-03	AURKB, FLT3, IGF1R, KDR, PIM1
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.332E-05	5.826E-03	CA12, CA4, CA7
BP	GO:0050896; response to stimulus	GO:0071417; cellular response to organonitrogen compound	2.758E-05	6.421E-03	IGF1R, MMP2, NFKB1, NOX4, NR1H4, TSHR
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	2.801E-05	6.421E-03	CYP1B1, CYP2C19, CYP3A4, RORC
BP	GO:0065007; biological regulation	GO:0048872; homeostasis of number of cells	2.999E-05	6.436E-03	AXL, FLT3, HIF1A, POLB
MF	GO:0003824; catalytic activity	GO:0004222; metalloendopeptidase activity	2.899E-05	6.436E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	3.484E-05	7.158E-03	CYP2C19, CYP3A4
BP	GO:0008152; metabolic process	GO:0019752; carboxylic acid metabolic process	3.679E-05	7.487E-03	ALOX12, CYP1B1, CYP2C19, HIF1A, HSD17B10, NOX4, NR1H4, PIM1
BP	GO:0009987; cellular process	GO:0001961; positive regulation of cytokine-mediated signaling pathway	4.001E-05	8.032E-03	AXL, HIF1A, MMP12
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.289E-05	8.476E-03	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0020037; heme binding	4.411E-05	8.576E-03	CYP1B1, CYP2C19, CYP3A4, NOX4
MF	GO:0005488; binding	GO:0005524; ATP binding	4.810E-05	9.015E-03	AURKB, AXL, CDK1, FLT3, IGF1R, KDR, MAP2K1, MET, PIM1, RECQL
MF	GO:0060089; molecular transducer activity	GO:0005021; vascular endothelial growth factor-activated receptor activity	4.873E-05	9.015E-03	FLT3, KDR

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	4.325E-09	5.666E-07	MAP2K1, FLT3, MMP1, MMP2, HIF1A, MET, MMP9, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.671E-08	1.095E-06	MAP2K1, MMP2, KDR, HIF1A, MMP9, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	4.007E-07	1.750E-05	MAP2K1, MMP1, MMP2, MMP9
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.537E-06	5.034E-05	MAP2K1, FLT3, PIM1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	2.952E-06	6.445E-05	MAP2K1, FLT3, MET, HIF1A
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	4.485E-06	8.393E-05	MAP2K1, PIM1, CYP1B1, MMP9, MET, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	2.038E-05	2.669E-04	MAP2K1, KDR, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	6.632E-06	1.086E-04	FLT3, MMP9, MET, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.640E-05	2.387E-04	MAP2K1, HIF1A, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	1.404E-04	1.533E-03	MAP2K1, KDR, MET, NFKB1, IGF1R
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.042E-06	5.349E-05	CA12, CA4, CA7
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	1.308E-04	1.533E-03	MAP2K1, MET, HIF1A
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	1.625E-04	1.637E-03	MAP2K1, MET, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	2.253E-04	2.108E-03	MAP2K1, KDR, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	2.661E-04	2.179E-03	MAP2K1, KDR, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	3.170E-04	2.443E-03	MAP2K1, NFKB1, IGF1R
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4.596E-04	3.010E-03	MMP2, PIM1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4.208E-04	2.989E-03	MAP2K1, CDK1, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	4.335E-04	2.989E-03	MAP2K1, MMP2, MMP9
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.490E-04	2.174E-03	CYP1B1, CYP3A4, CYP2C19
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	5.898E-04	3.679E-03	MAP2K1, MMP9, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	6.217E-04	3.702E-03	MAP2K1, ALOX12, CYP2C19
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	8.163E-04	4.649E-03	MAP2K1, CDK1, IGF1R
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	1.339E-03	7.017E-03	MAP2K1, MMP9, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	8.611E-04	4.700E-03	CYP3A4, CYP2C19

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R;
C00-D49: Neoplasms	CLL	NA	FLT3;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; MMP9;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; HIF1A; MMP9; MMP2;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; MMP2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1;
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	MMP12;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; NFKB1; FLT3; HIF1A; MMP9; MMP2;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR;
NA: NA	GIST	NA	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; MMP2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP1;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR; MMP2;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR; MMP2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases