Plant Name: Dolomiaea souliei
Taxonomic Information:
Plant ID: NPO10391
Plant Latin Name: Dolomiaea souliei
Taxonomy Genus: Dolomiaea
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
454324
Plant-of-the-World-Online:
943061-1
Used in Medicines:
Unknown.
Geographical Distribution:
China
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ALPL; ALOX12; ALOX15; HSD17B10; IDH1; USP2; | |
| GAA; | |
| TRPA1; | |
| PTGS2; PTGS1; MAOA; | |
| RELA; NFKB1; | |
| MAPT; LMNA; XBP1; | |
| FASN; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Enzyme_unclassified | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Enzyme_unclassified | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | IDH1 | Isocitrate dehydrogenase [NADP] cytoplasmic | O75874 | CHEMBL2007625 |
| Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Oxidoreductase | PTGS2 | Cyclooxygenase-2 | P35354 | CHEMBL230 |
| Oxidoreductase | PTGS1 | Cyclooxygenase-1 | P23219 | CHEMBL221 |
| Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
| Transcription Factor | RELA | Nuclear factor NF-kappa-B p65 subunit | Q04206 | CHEMBL5533 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Transferase | FASN | Fatty acid synthase | P49327 | CHEMBL4158 |
| Transient receptor potential channel | TRPA1 | Transient receptor potential cation channel subfamily A member 1 | O75762 | CHEMBL6007 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | XBP1 | X-box-binding protein 1 | P17861 | CHEMBL1741176 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 8.467E-12 | 1.468E-07 | ALOX12, ALOX15, CYP19A1, CYP2C19, CYP2C9, FASN, GAA, HSD17B10, IDH1, MAOA, PTGS1, PTGS2 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 1.691E-07 | 1.841E-04 | CYP19A1, CYP2C19, CYP2C9, PTGS1, PTGS2 |
| BP | GO:0008152; metabolic process | GO:0019372; lipoxygenase pathway | 5.270E-07 | 4.099E-04 | ALOX12, ALOX15, PTGS2 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 5.136E-07 | 4.099E-04 | ALOX12, ALOX15, CYP19A1, CYP2C19, CYP2C9 |
| BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 1.019E-06 | 6.523E-04 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0004666; prostaglandin-endoperoxide synthase activity | 1.019E-06 | 6.523E-04 | PTGS1, PTGS2 |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 1.019E-06 | 6.523E-04 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0050473; arachidonate 15-lipoxygenase activity | 3.054E-06 | 1.622E-03 | ALOX15, PTGS2 |
| MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 3.054E-06 | 1.622E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 3.054E-06 | 1.622E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 5.565E-06 | 2.885E-03 | CYP19A1, CYP2C19, CYP2C9 |
| BP | GO:0008152; metabolic process | GO:0051122; hepoxilin biosynthetic process | 1.017E-05 | 4.710E-03 | ALOX12, ALOX15 |
| BP | GO:0008152; metabolic process | GO:2000630; positive regulation of miRNA metabolic process | 1.017E-05 | 4.710E-03 | NFKB1, RELA |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 1.310E-05 | 5.822E-03 | CYP19A1, CYP2C19, CYP2C9 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.524E-05 | 6.507E-03 | CYP2C19, CYP2C9 |
| BP | GO:0032501; multicellular organismal process | GO:0045075; regulation of interleukin-12 biosynthetic process | 2.132E-05 | 8.452E-03 | NFKB1, RELA |
| BP | GO:0050896; response to stimulus | GO:0006979; response to oxidative stress | 2.135E-05 | 8.452E-03 | IDH1, PTGS1, PTGS2, RELA, TRPA1 |
| CC | GO:0032991; macromolecular complex | GO:0033256; I-kappaB/NF-kappaB complex | 2.132E-05 | 8.452E-03 | NFKB1, RELA |
| BP | GO:0008152; metabolic process | GO:0046890; regulation of lipid biosynthetic process | 2.344E-05 | 8.954E-03 | FASN, IDH1, NFKB1, PTGS2 |
| CC | GO:0016020; membrane | GO:0005789; endoplasmic reticulum membrane | 2.518E-04 | 4.768E-02 | CYP19A1, CYP2C19, CYP2C9, PTGS1, PTGS2, XBP1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 9.596E-12 | 5.109E-10 | MAOA, GAA, IDH1, ALOX15, ALOX12, PTGS2, CYP2C19, CYP19A1, HSD17B10, PTGS1, CYP2C9, FASN, ALPL |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 2.594E-11 | 8.473E-10 | CYP2C9, ALOX15, ALOX12, CYP2C19, PTGS2, PTGS1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.043E-11 | 5.109E-10 | CYP2C9, MAOA, ALOX15, ALOX12, CYP2C19, PTGS2, PTGS1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 3.073E-06 | 7.529E-05 | CYP2C9, ALOX15, CYP2C19 |
| 09160 Human Diseases | 09164 Substance dependence | hsa05030 | Cocaine addiction | 1.530E-05 | 2.999E-04 | MAOA, RELA, NFKB1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 4.296E-05 | 7.016E-04 | CYP2C9, MAOA, CYP2C19 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 5.086E-05 | 7.121E-04 | PTGS2, RELA, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 8.300E-05 | 9.038E-04 | PTGS2, RELA, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04668 | TNF signaling pathway | 1.724E-04 | 1.536E-03 | PTGS2, RELA, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 7.201E-05 | 8.821E-04 | CYP2C9, CYP2C19, PTGS2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04064 | NF-kappa B signaling pathway | 1.048E-04 | 1.027E-03 | PTGS2, RELA, NFKB1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 3.507E-04 | 2.864E-03 | LMNA, RELA, NFKB1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | 4.377E-04 | 3.299E-03 | XBP1, RELA, NFKB1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 1.131E-03 | 7.816E-03 | PTGS2, CYP19A1 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 1.467E-03 | 7.816E-03 | RELA, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 1.989E-03 | 7.816E-03 | MAPT, RELA, NFKB1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 1.416E-03 | 7.816E-03 | PTGS2, PTGS1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 1.367E-03 | 7.816E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05166 | HTLV-I infection | 2.056E-03 | 7.816E-03 | XBP1, RELA, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 1.961E-03 | 7.816E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09162 Immune diseases | hsa05321 | Inflammatory bowel disease (IBD) | 1.903E-03 | 7.816E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04621 | NOD-like receptor signaling pathway | 1.467E-03 | 7.816E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04623 | Cytosolic DNA-sensing pathway | 1.845E-03 | 7.816E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05131 | Shigellosis | 1.903E-03 | 7.816E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 2.080E-03 | 7.816E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 2.329E-03 | 7.816E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04662 | B cell receptor signaling pathway | 2.393E-03 | 7.816E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 2.393E-03 | 7.816E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 2.203E-03 | 7.816E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04622 | RIG-I-like receptor signaling pathway | 2.203E-03 | 7.816E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 2.524E-03 | 7.978E-03 | RELA, NFKB1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatitis | L20-L30 | PTGS1; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | PTGS1; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | PTGS1; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | PTGS1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | PTGS1; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Postoperative inflammation | T81 | PTGS1; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | PTGS1; |
| NA: NA | Miosis during ocular surgery | NA | PTGS1; |
| NA: NA | Rheumatold arthritis | NA | PTGS1; |
| C00-D49: Neoplasms | Colon cancer | C50 | ALPL; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1; |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | PTGS1; |
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL; |
| Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dietary shortage | E40-E46 | PTGS1; |
| C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | PTGS1; |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | PTGS1; |
| N00-N99: Diseases of the genitourinary system | Dysmenorrhea | N94.4-N94.6 | PTGS1; |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | PTGS1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
