CMAUP Plant Collective Molecular Activities

Plant Name: Scopolia carniolica

Taxonomic Information:

Plant ID: NPO10384
Plant Latin Name: Scopolia carniolica
Taxonomy Genus: Scopolia
Taxonomy Family: Solanaceae

Plant External Links:

NCBI TaxonomyDB: 258457
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China; South Korea; Croatia; Romania

Traditional Medicine System:

TCM

Medicinal Functions:

Antispasmodic; Hypnotic; Mydriatic; Narcotic

Geographical Distribution:

Croatia; Romania; China; South Korea

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CHRM1; CHRM2; CHRM3; CHRM5;
Enzyme_unclassified	BLM; ALDH1A1; GFER; HSD17B10; AKR1B10; AKR1B1; POLB;
Lyase	CA7; CA12; CA1; CA9; CA13;
Cysteine protease	CASP7; CASP1;
Transcription Factor	NFKB1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Small molecule receptor (family A GPCR)	CHRM1	Muscarinic acetylcholine receptor M1	P11229	CHEMBL216
Small molecule receptor (family A GPCR)	CHRM2	Muscarinic acetylcholine receptor M2	P08172	CHEMBL211
Small molecule receptor (family A GPCR)	CHRM3	Muscarinic acetylcholine receptor M3	P20309	CHEMBL245
Small molecule receptor (family A GPCR)	CHRM5	Muscarinic acetylcholine receptor M5	P08912	CHEMBL2035
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0007197; adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway	4.175E-12	3.030E-08	CHRM1, CHRM2, CHRM3, CHRM5
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.065E-12	3.030E-08	CA1, CA12, CA13, CA7, CA9
MF	GO:0060089; molecular transducer activity	GO:0016907; G-protein coupled acetylcholine receptor activity	4.175E-12	3.030E-08	CHRM1, CHRM2, CHRM3, CHRM5
BP	GO:0050896; response to stimulus	GO:0007207; phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway	1.252E-11	6.814E-08	CHRM1, CHRM2, CHRM3, CHRM5
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.558E-10	9.283E-07	CA1, CA12, CA13, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	7.330E-10	2.280E-06	CA1, CA12, CA13, CA7, CA9
BP	GO:0023052; signaling	GO:0007271; synaptic transmission, cholinergic	1.444E-08	2.419E-05	CHRM1, CHRM2, CHRM3, CHRM5
MF	GO:0003824; catalytic activity	GO:0004435; phosphatidylinositol phospholipase C activity	2.733E-06	2.834E-03	CHRM1, CHRM3, CHRM5
BP	GO:0032501; multicellular organismal process	GO:0046541; saliva secretion	1.017E-05	9.224E-03	CHRM1, CHRM3
MF	GO:0003824; catalytic activity	GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors	1.224E-05	1.066E-02	AKR1B1, AKR1B10, ALDH1A1
MF	GO:0003824; catalytic activity	GO:0001758; retinal dehydrogenase activity	2.132E-05	1.658E-02	AKR1B10, ALDH1A1
CC	GO:0044456; synapse part	GO:0043679; axon terminus	2.406E-05	1.807E-02	CHRM1, CHRM2, CHRM3
CC	GO:0045202; synapse	GO:0032279; asymmetric synapse	2.841E-05	1.875E-02	CHRM2, CHRM3
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	5.845E-05	3.030E-02	CHRM1, CHRM2, CHRM3, CHRM5

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.573E-12	2.894E-10	CA12, CA1, CA7, CA9, CA13
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	4.065E-06	1.646E-04	CHRM2, CHRM3, CHRM1, CHRM5
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	2.747E-05	5.562E-04	CHRM2, CHRM3, CHRM1, CHRM5
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	2.170E-05	5.562E-04	CASP7, CASP1, NFKB1
09140 Cellular Processes	09142 Cell motility	hsa04810	Regulation of actin cytoskeleton	5.398E-05	7.445E-04	CHRM2, CHRM3, CHRM1, CHRM5
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	5.515E-05	7.445E-04	CASP7, CASP1, NFKB1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.465E-04	1.695E-03	CHRM2, CHRM3, CHRM1, CHRM5
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	9.763E-04	7.189E-03	CHRM2, CHRM1, NFKB1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5.864E-04	4.750E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	4.064E-04	4.115E-03	AKR1B10, AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	1.571E-03	9.788E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4.628E-04	4.165E-03	AKR1B10, AKR1B1
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	1.467E-03	9.788E-03	CASP1, NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CHRM1; CHRM5;
L00-L99: Diseases of the skin and subcutaneous tissue	Seborrhea	L21	CHRM3;
G00-G99: Diseases of the nervous system G00-G99	Brain diseases	G00-G99	CHRM5;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
I00-I99: Diseases of the circulatory system	Heart failure	I50	CHRM2;
NA: NA	Schizoaffective disorders	NA	CHRM1;
NA: NA	Dystonia	NA	CHRM1;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	CHRM5;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	CHRM1; CHRM3; CHRM5;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	CHRM3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	CHRM1; CHRM5;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
G00-G99: Diseases of the nervous system G00-G99	Central and peripheral nervous diseases	G96.9	CHRM5;
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	CHRM1; CHRM5;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	CHRM1; CHRM2; CHRM3; CHRM5;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Visceral spasms	R25.2	CHRM1;
NA: NA	Functional bowel syndrome	NA	CHRM1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	CHRM1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Postoperative nausea and vomiting	R11	CHRM3;
N00-N99: Diseases of the genitourinary system	Overactive bladder	N32.81	CHRM3;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	CHRM1; CHRM3;
NA: NA	Excessive sweating	NA	CHRM1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	CHRM1; CHRM2; CHRM3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CHRM3;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	CHRM1; CHRM2;
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	CHRM1; CHRM2;
K00-K95: Diseases of the digestive system	Stomach ulcer	K25-K27	CHRM1; CHRM5;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Stabilize muscle contractions	M00-M99	CHRM2;
J00-J99: Diseases of the respiratory system	Asthma	J45	CHRM2;
J00-J99: Diseases of the respiratory system	Obstructive lung diseases	J40-J44, J47	CHRM3;
NA: NA	Addiction	NA	CHRM2;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	CHRM5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Amnesia	F04	CHRM5;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	CHRM1; CHRM5;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnosing bronchial hyperreactivity	W88	CHRM3;
K00-K95: Diseases of the digestive system	Colitis	K50-K52	CHRM5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	CHRM1;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	CHRM5;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	CHRM1;
NA: NA	Abdominal stomach pain	NA	CHRM1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	CHRM2;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
NA: NA	Spasms	NA	CHRM3;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
NA: NA	Extrapyramidal disorders secondary to neuroleptic drug therapy	NA	CHRM1;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	CHRM2;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CHRM1; CHRM3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Sjogren's syndrome	M35.0	CHRM3;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases