CMAUP Plant Collective Molecular Activities

Plant Name: Ophiorrhiza liukiuensis

Taxonomic Information:

Plant ID: NPO1034
Plant Latin Name: Ophiorrhiza liukiuensis
Taxonomy Genus: Ophiorrhiza
Taxonomy Family: Rubiaceae

Plant External Links:

NCBI TaxonomyDB: 489897
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Lyase	CA7; CA12; CA9;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	ALDH1A1; GFER; HSD17B10; AKR1B10; AKR1B1;
Cysteine protease	CASP7; CASP1;
Transcription Factor	NFKB1;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP3A4; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.131E-08	1.458E-04	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	4.526E-08	1.971E-04	AKR1B1, AKR1B10, CYP1A2, CYP2D6, CYP3A4, NR1H4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.240E-07	2.999E-04	CYP1A2, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.559E-07	5.573E-04	CA12, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	9.919E-07	1.800E-03	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	2.186E-06	3.400E-03	CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0017144; drug metabolic process	3.882E-06	5.008E-03	AKR1B1, AKR1B10, ALDH1A1, CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.971E-06	5.008E-03	CA12, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	4.370E-06	5.008E-03	CYP1A2, CYP3A4
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	7.333E-06	7.604E-03	CA12, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors	7.333E-06	7.604E-03	AKR1B1, AKR1B10, ALDH1A1
MF	GO:0005488; binding	GO:0019825; oxygen binding	7.853E-06	7.773E-03	CYP1A2, CYP2D6, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.443E-07	2.479E-05	CA12, CA7, CA9
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.302E-05	3.980E-04	CASP7, CASP1, NFKB1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.157E-05	3.980E-04	CYP1A2, ALDH1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.581E-05	3.980E-04	CYP2D6, CYP1A2, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.058E-05	3.980E-04	CYP2D6, CYP1A2, CYP3A4
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	3.316E-05	3.980E-04	CASP7, CASP1, NFKB1
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.819E-04	2.500E-03	AKR1B10, CYP1A2, ALDH1A1, AKR1B1, CYP3A4, HSD17B10
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	3.631E-04	2.500E-03	CASP7, MAPT, HSD17B10
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.724E-04	2.500E-03	CYP1A2, CYP3A4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	2.917E-04	2.500E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4.212E-04	2.527E-03	AKR1B10, AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	1.131E-03	5.428E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3.323E-04	2.500E-03	AKR1B10, AKR1B1
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	1.056E-03	5.428E-03	CASP1, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.093E-03	5.428E-03	CYP1A2, CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.633E-03	6.915E-03	NR1H4, CYP3A4
09150 Organismal Systems	09151 Immune system	hsa04623	Cytosolic DNA-sensing pathway	1.329E-03	5.981E-03	CASP1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.170E-03	8.680E-03	CYP1A2, CYP3A4
09160 Human Diseases	09167 Infectious diseases	hsa05132	Salmonella infection	2.383E-03	9.032E-03	CASP1, NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Renal cancer	C64	CA9;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases