Plant Name: Scrophularia leucoclada
Taxonomic Information:
Plant ID: NPO1027
Plant Latin Name: Scrophularia leucoclada
Taxonomy Genus: Scrophularia
Taxonomy Family: Scrophulariaceae
Plant External Links:
NCBI TaxonomyDB:
1042512
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| OPRD1; | |
| CNR2; | |
| NR1H4; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Peptide receptor (family A GPCR) | OPRD1 | Delta opioid receptor | P41143 | CHEMBL236 |
| Small molecule receptor (family A GPCR) | CNR2 | Cannabinoid CB2 receptor | P34972 | CHEMBL253 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0032501; multicellular organismal process | GO:0019233; sensory perception of pain | 2.212E-05 | 1.879E-01 | CNR2, OPRD1 |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 1.050E-04 | 1.879E-01 | CNR2, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0004949; cannabinoid receptor activity | 4.659E-04 | 3.382E-01 | CNR2 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 4.659E-04 | 3.382E-01 | NR1H4 |
| MF | Unclassified; | GO:0004872; receptor activity | 5.208E-04 | 3.656E-01 | CNR2, NR1H4, OPRD1 |
| MF | GO:0060089; molecular transducer activity | GO:0004887; thyroid hormone receptor activity | 1.087E-03 | 4.926E-01 | NR1H4 |
| CC | GO:0044456; synapse part | GO:0097060; synaptic membrane | 4.392E-02 | 1.000E+00 | OPRD1 |
| CC | GO:0016020; membrane | GO:0045121; membrane raft | 4.482E-02 | 1.000E+00 | OPRD1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 5.682E-04 | 2.273E-03 | OPRD1, CNR2 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.061E-02 | 2.123E-02 | NR1H4 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 1.789E-02 | 2.386E-02 | OPRD1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04022 | cGMP-PKG signaling pathway | 2.484E-02 | 2.484E-02 | OPRD1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | CNR2; |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | CNR2; |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | CNR2; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis | M80-M81, Z79.890 | CNR2; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | CNR2; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Atopic dermatitis | L00-L99 | CNR2; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Immune disorder | D80-D89 | CNR2; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CNR2; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
