CMAUP Plant Collective Molecular Activities

Plant Name: Crotalaria assamica

Taxonomic Information:

Plant ID: NPO10262
Plant Latin Name: Crotalaria assamica
Taxonomy Genus: Crotalaria
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 671522
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Thailand; China

Traditional Medicine System:

TCM

Geographical Distribution:

Thailand; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ACHE;
Enzyme_unclassified	EBP; HSD17B10; HSD17B1;
Protein Kinase	CSNK2A1;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Lysine demethylase	KDM4E;
Unclassified	EBPL; THPO; SIGMAR1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP2D6; CYP1A2; CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Enzyme_unclassified	EBP	3-beta-hydroxysteroid-delta(8),delta(7)-isomerase	Q15125	CHEMBL4931
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Unclassified	EBPL	Emopamil-binding protein-like	Q9BY08	CHEMBL2311238
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	SIGMAR1	Sigma opioid receptor	Q99720	CHEMBL287

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	4.477E-12	4.874E-08	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.610E-10	7.012E-07	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6
MF	GO:0005488; binding	GO:0020037; heme binding	3.364E-08	9.155E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	4.532E-08	1.068E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.029E-07	1.422E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	1.237E-07	1.584E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EBP, EBPL, SIGMAR1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	4.997E-07	5.727E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0047750; cholestenol delta-isomerase activity	5.629E-07	6.128E-04	EBP, EBPL
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	6.647E-07	6.893E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	2.235E-06	1.390E-03	CYP19A1, CYP1A1, CYP2D6
BP	GO:0008152; metabolic process	GO:0016125; sterol metabolic process	2.373E-06	1.435E-03	CYP19A1, CYP1B1, EBP, EBPL
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.374E-06	1.951E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0032451; demethylase activity	3.405E-06	1.951E-03	CYP1A1, CYP1A2, KDM4E
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	8.428E-06	4.588E-03	CYP1A2, CYP2D6
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	1.179E-05	5.837E-03	CYP1A2, CYP2D6
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	1.179E-05	5.837E-03	CYP1A1, CYP2D6
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	1.572E-05	7.440E-03	CYP1A1, CYP1A2

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5.050E-10	1.515E-08	HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	4.622E-08	6.933E-07	HSD17B1, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.162E-07	2.162E-06	CYP2D6, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	3.316E-06	2.487E-05	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.917E-05	1.750E-04	CYP1A2, CYP1A1, CYP1B1
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.720E-04	8.598E-04	EBP, HSD17B1, CYP1A2, CYP1A1, CYP19A1, HSD17B10
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.063E-03	4.487E-03	CYP1A2, CYP1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.196E-03	4.487E-03	CYP2D6, CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	EBP;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Cancer	C00-C96	CSNK2A1; ACHE;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases