CMAUP Plant Collective Molecular Activities

Plant Name: Liquidambar orientalis

Taxonomic Information:

Plant ID: NPO10256
Plant Latin Name: Liquidambar orientalis
Taxonomy Genus: Liquidambar
Taxonomy Family: Altingiaceae

Plant External Links:

NCBI TaxonomyDB: 63360
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China; Iraq; India

Traditional Medicine System:

Indian Folk; TCM; Unani; Ayurveda; Siddha

Medicinal Functions:

Antibacterial; Antidote; Antiinflammatory; Parasiticide; Pectoral; Salve; Stimulant; Vulnerary

Geographical Distribution:

India; Iraq; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family A GPCR)	HCAR2;
Protein Phosphatase	PTPN1; PTPN2;
Enzyme_unclassified	TDP1; ALDH1A1;
Lyase	CA3; CA14; CA4; CA6; CA12; CA1; CA9; CA5B; CA5A; CA7; CA2;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Unclassified	HTT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2A6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	5.914E-12	1.288E-08	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR2, PTPN1
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.377E-31	2.999E-27	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	7.633E-25	8.310E-21	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.375E-06	5.249E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	6.746E-06	9.180E-03	PTPN1, PTPN2
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.450E-23	2.422E-19	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.684E-05	1.930E-02	CA1, CA2
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	4.383E-05	4.544E-02	CA2, CA4, CA9, TSHR
BP	GO:0009987; cellular process	GO:1903897; regulation of PERK-mediated unfolded protein response	5.039E-05	4.771E-02	PTPN1, PTPN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.508E-31	2.467E-29	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2.622E-04	3.801E-03	CA2, CA4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.099E-03	2.029E-02	CYP2A6, ALDH1A1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.827E-02	1.060E-01	HCAR2, TSHR
09150 Organismal Systems	09155 Excretory system	hsa04966	Collecting duct acid secretion	2.798E-02	1.277E-01	CA2
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5.721E-02	1.277E-01	TSHR
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	5.423E-02	1.277E-01	TSHR
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7.004E-02	1.277E-01	CYP2A6
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	7.297E-02	1.277E-01	ESR2
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	5.240E-03	3.799E-02	CYP2A6

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases