CMAUP Plant Collective Molecular Activities

Plant Name: Heynea trijuga

Taxonomic Information:

Plant ID: NPO10230
Plant Latin Name: Heynea trijuga
Taxonomy Genus: Heynea
Taxonomy Family: Meliaceae

Plant External Links:

NCBI TaxonomyDB: 1495524
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Thailand; India

Traditional Medicine System:

Indian Folk; Siddha

Geographical Distribution:

Thailand; India

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family A GPCR)	GPBAR1;
Enzyme_unclassified	BLM; ALOX15; HSD17B10; AKR1B10;
Protein Kinase	PIM1; CSNK2A1;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Nuclear hormone receptor subfamily 3 group A	ESR1; ESR2;
Transcription Factor	HIF1A;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0046914; transition metal ion binding	3.949E-07	4.085E-03	ALOX15, BLM, CYP2C9, CYP3A4, ESR1, ESR2, NR1H4, PIM1
MF	GO:0005488; binding	GO:0005496; steroid binding	4.815E-07	4.085E-03	CYP3A4, ESR1, ESR2, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	5.629E-07	4.085E-03	ESR1, ESR2
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	8.881E-07	4.369E-03	AKR1B10, CYP2C9, CYP3A4, ESR1, NR1H4
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	1.688E-06	5.250E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	1.688E-06	5.250E-03	GPBAR1, NR1H4
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	3.374E-06	7.347E-03	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	3.374E-06	7.347E-03	CYP2C9, CYP3A4
BP	GO:0009987; cellular process	GO:0009755; hormone-mediated signaling pathway	6.830E-06	1.063E-02	ESR1, ESR2, NR1H4, TSHR
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	8.219E-06	1.147E-02	ESR1, ESR2, NR1H4, PIM1
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	8.428E-06	1.147E-02	CYP2C9, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.233E-06	6.286E-05	CYP2C9, ALOX15, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	9.673E-04	9.544E-03	CYP2C9, ALOX15
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.063E-03	9.544E-03	CYP2C9, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.302E-03	9.544E-03	ESR1, ESR2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.196E-03	9.544E-03	CYP2C9, CYP3A4
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.610E-03	9.544E-03	CYP2C9, AKR1B10, ALOX15, CYP3A4, HSD17B10
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.266E-03	9.544E-03	NR1H4, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.338E-03	9.544E-03	CYP2C9, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	2.442E-03	1.245E-02	ESR1, ESR2
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.684E-03	9.544E-03	CYP2C9, CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases